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  1. No Access

    Article

    Atp8a1 deletion increases the proliferative activity of hematopoietic stem cells by impairing PTEN function

    The eukaryotic cell plasma membrane contains several asymmetrically distributed phospholipids, which is maintained by the P4-ATPase flippase complex. Herein, we demonstrated the biological effects and mechanis...

    Li Zheng, Cong Pan, Wanli Tian, Cailing Liang, Yunyu Feng, Wei He… in Cellular Oncology (2023)

  2. Article

    Open Access

    TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN

    We report herein that TSPAN32 is a key node factor for Philadelphia (Ph+) leukemia pathogenesis. We found that TSPAN32 expression was repressed by BCR-ABL and ectopic TSPAN32 expression upon Imatinib treatment in...

    Qiang Qiu, Yuanyuan Sun, Linyu Yang… in Signal Transduction and Targeted Therapy (2023)

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  3. No Access

    Article

    FLI1 accelerates leukemogenesis through transcriptional regulation of pyruvate kinase-L/R and other glycolytic genes

    In cancer cells, multiple oncogenes and tumor suppressors control glycolysis to sustain rapid proliferation. The ETS-related transcription factor Fli1 plays a critical role in the induction and progression of ...

    Danmei Sheng, Beiling Chen, Chunlin Wang, **ao **ao, Anling Hu… in Medical Oncology (2022)