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  1. Article

    Open Access

    TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN

    We report herein that TSPAN32 is a key node factor for Philadelphia (Ph+) leukemia pathogenesis. We found that TSPAN32 expression was repressed by BCR-ABL and ectopic TSPAN32 expression upon Imatinib treatment in...

    Qiang Qiu, Yuanyuan Sun, Linyu Yang… in Signal Transduction and Targeted Therapy (2023)

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  2. No Access

    Article

    Current insights into the role of Fli-1 in hematopoiesis and malignant transformation

    Fli-1, a member of the ETS family of transcription factors, was discovered in 1991 through retroviral insertional mutagenesis as a driver of mouse erythroleukemias. In the past 30 years, nearly 2000 papers hav...

    Yaacov Ben-David, Babu Gajendran, Klarke M. Sample… in Cellular and Molecular Life Sciences (2022)

  3. No Access

    Chapter

    Erythropoietin Signaling in the Microenvironment of Tumors and Healthy Tissues

    Erythropoietin (EPO), the primary cytokine of erythropoiesis, stimulates both proliferation and differentiation of erythroid progenitors and their maturation to red blood cells. Basal EPO levels maintain the opti...

    Wuling Liu, Krishnapriya M. Varier, Klarke M. Sample… in Tumor Microenvironment (2020)