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  1. No Access

    Article

    Atp8a1 deletion increases the proliferative activity of hematopoietic stem cells by impairing PTEN function

    The eukaryotic cell plasma membrane contains several asymmetrically distributed phospholipids, which is maintained by the P4-ATPase flippase complex. Herein, we demonstrated the biological effects and mechanis...

    Li Zheng, Cong Pan, Wanli Tian, Cailing Liang, Yunyu Feng, Wei He… in Cellular Oncology (2023)

  2. No Access

    Article

    A critical ETV4/Twist1/Vimentin axis in Ha-RAS-induced aggressive breast cancer

    RAS oncogenes are major drivers of diverse types of cancer. However, they are largely not druggable, and therefore targeting critical downstream pathways and dependencies is an attractive approach. We have iso...

    Wuling Liu, Babu Gajendran, Klarke M. Sample, Chunlin Wang… in Cancer Gene Therapy (2022)

  3. No Access

    Article

    Current insights into the role of Fli-1 in hematopoiesis and malignant transformation

    Fli-1, a member of the ETS family of transcription factors, was discovered in 1991 through retroviral insertional mutagenesis as a driver of mouse erythroleukemias. In the past 30 years, nearly 2000 papers hav...

    Yaacov Ben-David, Babu Gajendran, Klarke M. Sample… in Cellular and Molecular Life Sciences (2022)

  4. Article

    Open Access

    ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes

    Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good or p...

    Fang Yu, Babu Gajendran, Ning Wang, Klarke M. Sample, Wuling Liu… in BMC Cancer (2021)

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