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  1. No Access

    Article

    ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung

    Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a commonly affected organ. We found that activation of lung-resident group 2 innate lymphoid cells (ILC2s) orchestrated su...

    Martijn J. Schuijs, Shaun Png, Arianne C. Richard, Anastasia Tsyben… in Nature Immunology (2020)

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    Article

    Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose

    One of the most likely substrates for metabolic imaging of response to treatment in cancer is glucose, but until now, using hyperpolarized 13C-labelled glucose has been problematic because of the short lifetim...

    Tiago B Rodrigues, Eva M Serrao, Brett W C Kennedy, De-En Hu… in Nature Medicine (2014)

  3. No Access

    Article

    Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus

    Cell-surface glycans are known to alter as Barrett's esophagus progresses to adenocarcinoma, leading to specific changes in lectin binding patterns. Bird-Lieberman and her colleagues have exploited this knowle...

    Elizabeth L Bird-Lieberman, André A Neves, Pierre Lao-Sirieix… in Nature Medicine (2012)

  4. Article

    Erratum: Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy

    Nat. Med. 13, 1382–1387 (2007); published online 28 October 2007; corrected after print 12 November 2007. In the version of this article initially published, Equation 2 is incorrect. The correct equation is: A...

    Sam E Day, Mikko I Kettunen, Ferdia A Gallagher, De-En Hu… in Nature Medicine (2007)

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    Article

    Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy

    Measurements of early tumor responses to therapy have been shown, in some cases, to predict treatment outcome. We show in lymphoma-bearing mice injected intravenously with hyperpolarized [1-13C]pyruvate that the ...

    Sam E Day, Mikko I Kettunen, Ferdia A Gallagher, De-En Hu… in Nature Medicine (2007)

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    Article

    Proton NMR analysis of plasma is a weak predictor of coronary artery disease

    Multivariate analysis of 1H-NMR spectra of blood sera was reported previously to predict angiographically defined advanced coronary artery disease (CAD) with >90% accuracy and specificity. The analysis depended m...

    Heide L Kirschenlohr, Julian L Griffin, Sarah C Clarke, Ranyl Rhydwen… in Nature Medicine (2006)

  7. No Access

    Article

    Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent

    The C2 domain of synaptotagmin I, which binds to anionic phospholipids in cell membranes, was shown to bind to the plasma membrane of apoptotic cells by both flow cytometry and confocal microscopy. Conjugation of...

    Ming Zhao, Daniel A. Beauregard, Louiza Loizou, Bazbek Davletov… in Nature Medicine (2001)