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  1. No Access

    Article

    Targeting a lineage-specific PI3Kɣ–Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule

    Dose-limiting toxicity poses a major limitation to the clinical utility of targeted cancer therapies, often arising from target engagement in nonmalignant tissues. This obstacle can be minimized by targeting c...

    Lois M. Kelly, Justine C. Rutter, Kevin H. Lin, Frank Ling… in Nature Cancer (2024)

  2. No Access

    Article

    P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia

    Selinexor is a first-in-class inhibitor of the nuclear exportin XPO1 that was recently approved by the US Food and Drug Administration for the treatment of multiple myeloma and diffuse large B-cell lymphoma. I...

    Kevin H. Lin, Justine C. Rutter, Abigail **e, Shane T. Killarney… in Nature Cancer (2022)