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Article
The economic burden of inherited retinal disease in Singapore: a prevalence-based cost-of-illness study
To assess the economic impact of inherited retinal disease (IRD) among Singaporeans.
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Article
Open AccessEmerging therapeutic strategies for unmet need in neovascular age-related macular degeneration
Neovascular age-related macular degeneration (nAMD) is a major cause of visual impairment and blindness. Anti-vascular endothelial growth factor (VEGF) agents, such as ranibizumab, bevacizumab, aflibercept, br...
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Article
Longer treatment intervals are associated with reduced treatment persistence in neovascular age related macular degeneration
To test the hypothesis that patients treated for neovascular age related macular degeneration (nAMD) with longer treatment intervals are more likely to persist with treatment.
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Article
Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons
Synonymous and noncoding single nucleotide polymorphisms (SNPs) in the KCNJ6 gene, encoding G protein-gated inwardly rectifying potassium channel subunit 2 (GIRK2), have been linked with increased electroencephal...
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Article
Open AccessDiagnostic potential of the amniotic fluid cells transcriptome in deciphering mendelian disease: a proof-of-concept
RNA sequencing (RNA-seq) is emerging in genetic diagnoses as it provides functional support for the interpretation of variants of uncertain significance. However, the use of amniotic fluid (AF) cells for RNA-s...
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Article
Real-world cost-effectiveness of anti-VEGF monotherapy and combination therapy for the treatment of polypoidal choroidal vasculopathy
For patients with polypoidal choroidal vasculopathy (PCV), intravitreal anti-vascular endothelial growth factor (anti-VEGF) combination therapy has been shown to be cost-saving relative to monotherapy in a cli...
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Article
Strong yet ductile nanolamellar high-entropy alloys by additive manufacturing
Additive manufacturing produces net-shaped components layer by layer for engineering applications1–7. The additive manufacture of metal alloys by laser powder bed fusion (L-PBF) involves large temperature gradien...
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Article
Effect of local twin Schmid factor on the tension twinning activities in a highly textured Mg–3Al–1Zn alloy under different strain paths
We investigated the effect of the local twin Schmid factor (SF) on the tension twinning of individual grains in deformed textured Mg–3Al–1Zn samples under various strain paths. Statistical analyses on the elec...
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Article
Identifying the content for an item bank and computerized adaptive testing system to measure the impact of age-related macular degeneration on health-related quality of life
We are develo** an age-related macular degeneration (AMD) health-related quality of life (HRQoL) item bank, applicable to Western and Asian populations. We report primarily on content generation and refineme...
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Article
Open AccessXrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA
The existence of non-canonical nicotinamide adenine diphosphate (NAD) 5′-end capped RNAs is now well established. Nevertheless, the biological function of this nucleotide metabolite cap remains elusive. Here, ...
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Article
Open AccessEvolving treatment paradigms for PCV
Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular AMD (nAMD) that accounts for a significant proportion of nAMD cases worldwide, and particularly in Asia. Contemporary PCV treatment strategie...
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Article
Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells
Recent technological advances have enabled massively parallel chromatin profiling with scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here we present ATAC with select antige...
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Chapter
Economic Implications of Post-traumatic Arthritis of the Hip and Knee
Osteoarthritis (OA) currently affects over 27 million people and ranks among the top 5 most costly conditions to manage in the United States along with heart disease, cancer, mental disorders, and trauma-relat...
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Article
Risk factors associated with persistent chronic opioid use following THA
An understanding of patient characteristics associated with persistent chronic opioid use after total joint arthroplasty (TJA) will allow surgeons to better manage these patients. Our study aims to identify ri...
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Article
Open AccessIdentification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants
Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-an...
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Chapter
Cost-Effectiveness Analysis of Robotic Arthroplasty
Robotic-assisted technology was introduced into orthopedic procedures nearly two decades ago with the hope of reducing human error by improving mechanical alignment and joint kinematics. Four robotic systems a...
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Article
Open AccessIdentifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES)
Whole-exome sequencing (WES) has become an invaluable tool for genetic diagnosis in paediatrics. However, it has not been widely adopted in the prenatal setting. This study evaluated the use of WES in prenatal...
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Article
Open AccessIntegrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies
RASopathies are a group of heterogeneous conditions caused by germline mutations in RAS/MAPK signalling pathway genes. With next-generation sequencing (NGS), sequencing capacity is no longer a limitation to mo...
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Article
Single-Cell Transcriptome Analysis of Neural Stem Cells
Neural stem cells (NSCs) in the adult central nervous system play essential roles in both normal homeostasis and repair of damaged tissue after injury. The study of adult NSCs is hampered by the heterogeneous ...
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Chapter
Paediatric Robotic Surgery: Complications
Robotic surgery has been introduced to extend the capabilities of surgeons and address the difficulties and morbidities encountered with laparoscopic surgery (minimal access surgery). The application of roboti...
