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Article
Open AccessSUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation
The platelet-derived growth factor (PDGF) family of ligands exerts their cellular effects by binding to α- and β-tyrosine kinase receptors (PDGFRα and PDGFRβ, respectively). SUMOylation is an important posttra...
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Article
Open AccessDeubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling
Interaction of platelet-derived growth factor (PDGF) isoforms with their receptors results in activation and internalization of receptors, with a concomitant activation of downstream signalling pathways. Ubiqu...
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Article
Open AccessEffect of porosities on tensile properties of laser-welded Al-Li alloy: an experimental and modelling study
Aluminium–lithium (Al-Li) alloys are very attractive for aerospace applications due to their outstanding properties, such as high specific strength, high rigidity and good resistance to corrosion and fatigue, ...