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within Kazuya Ogawa Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. Article

    Open Access

    Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures

    Starting with the clinical application of two vaccines in 2020, mRNA therapeutics are currently being investigated for a variety of applications. Removing immunogenic uncapped mRNA from transcribed mRNA is cri...

    Masahito Inagaki, Naoko Abe, Zhenmin Li, Yuko Nakashima… in Nature Communications (2023)

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  2. Article

    Open Access

    Three-dimensional conditional generative adversarial network-based virtual thin-slice technique for the morphological evaluation of the spine

    Virtual thin-slice (VTS) technique is a generative adversarial network-based algorithm that can generate virtual 1-mm-thick CT images from images of 3–10-mm thickness. We evaluated the performance of VTS techn...

    Atsushi Nakamoto, Masatoshi Hori, Hiromitsu Onishi, Takashi Ota… in Scientific Reports (2022)

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  3. No Access

    Article

    A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells

    The cytokine leukaemia inhibitory factor (LIF) integrates signals into mouse embryonic stem cells to maintain pluripotency. The Jak-Stat3 pathway is known to mediate LIF signals, but it is not clear how these ...

    Hitoshi Niwa, Kazuya Ogawa, Daisuke Shimosato, Kenjiro Adachi in Nature (2009)