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  1. Article

    Open Access

    The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity

    Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In so...

    Mark F. Maurer, Katherine E. Lewis, Joseph L. Kuijper… in Nature Communications (2022)

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