12 Result(s)
within
Kartik Chandran
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessPrefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge
Ever-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the effectiveness of therapeutic antibodies and vaccines. Develo** a coronavirus vaccine that offers a greater breadth of protection agains...
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Open AccessAuthor Correction: Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection
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Open AccessTwo point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection
Andes virus (ANDV) and Sin Nombre virus (SNV) are the etiologic agents of severe hantavirus cardiopulmonary syndrome (HCPS) in the Americas for which no FDA-approved countermeasures are available. Protocadheri...
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Open AccessFunctional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response
Transfer of convalescent plasma (CP) had been proposed early during the SARS-CoV-2 pandemic as an accessible therapy, yet trial results worldwide have been mixed, potentially due to the heterogeneous nature of...
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Author Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Protocadherin-1 is essential for cell entry by New World hantaviruses
The zoonotic transmission of hantaviruses from their rodent hosts to humans in North and South America is associated with a severe and frequently fatal respiratory disease, hantavirus pulmonary syndrome (HPS)1,2....
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Publisher Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome
Change history: In the HTML version of this Letter, Extended Data Fig. 4 incorrectly corresponded to Fig. 4 (the PDF version of the figure was correct). This has been corrected online.
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A naturally occurring antiviral ribonucleotide encoded by the human genome
Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding of the processes that contribute to viral life cycles is necessary for the development of new...
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How to turn competitors into collaborators
Erica Ollmann Saphire and colleagues share lessons in finding treatments fast from the work on Ebola by the Viral Hemorrhagic Fever Immunotherapeutic Consortium.
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Open AccessBispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses
Filoviruses (Ebola and Marburg) cause severe hemorrhagic fever. There are five species of ebolavirus; among these, the Ebola (Zaire) and Sudan viruses (EBOV and SUDV, respectively) are highly pathogenic and ha...
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Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
The extraordinary virulence of the Ebola and Marburg filoviruses has spurred intensive research into the molecular mechanisms by which they multiply and cause disease. Carette et al. use a genome-wide genetic scr...
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Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection
The extraordinary virulence of the Ebola and Marburg filoviruses has spurred intensive research into the molecular mechanisms by which they multiply and cause disease. Carette et al. use a genome-wide genetic scr...
