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  1. No Access

    Article

    Comparison of SLCO1B1 sequence variability among German, Turkish, and African populations

    OATP1B1 is one of the key hepatocellular uptake transporters providing extraction of diverse compounds, including bile acids, xenobiotics, and a variety of drugs, from portal venous blood into the liver. Polym...

    Jessica Mwinyi, Karla Köpke, Melanie Schaefer… in European Journal of Clinical Pharmacology (2008)

  2. No Access

    Article

    Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers

    The multidrug resistance gene 1 (MDR1) seems to play a role in the carcinogenesis of colorectal tumors. The importance of MDR1 SNPs 2677G > T/A in exon 21 and 3435C > T in exon 26 for cancer susceptibility, howev...

    Elena Osswald, Andreas Johne… in European Journal of Clinical Pharmacology (2007)

  3. No Access

    Article

    Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population

    The frequency of functionally important mutations and alleles of genes coding for xenobiotic metabolizing enzymes shows a wide ethnic variation. However, little is known of the frequency distribution of the ma...

    Elena A. Gaikovitch, Ingolf Cascorbi… in European Journal of Clinical Pharmacology (2003)

  4. No Access

    Article

    β1-Adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?

    A substantial body of evidence suggests involvement of the human β1-adrenoceptor (β1-AR) gene in the pathophysiology of dilated cardiomyopathy (DCM), a severe heart disease of significant public health impact. β1

    Svenia Podlowski, Katrin Wenzel, Hans P. Luther… in Journal of Molecular Medicine (2000)