16 Result(s)
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Open AccessNoise annoyance and cardiovascular disease risk: results from a 10-year follow-up study
The relationship between noise annoyance and risk of cardiovascular disease (CVD) still needs to be fully elucidated. Thus, we examined the relationship between noise annoyance and CVD risk in a large populati...
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Article
Open AccessSelf-rated physical health predicts mortality in aging persons beyond objective health risks
Previous studies on self-rated health and mortality have usually not differentiated between physical and mental health, respectively have not considered physical diseases. This study aims to determine self-rat...
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Open AccessAssociation of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis
Animal experiments and early phase human trials suggest that inhibition of factor XIa (FXIa) safely prevents venous thromboembolism (VTE), and specific murine models of sepsis have shown potential efficacy in ...
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Open AccessRight atrium size in the general population
Echocardiography is the most common routine cardiac imaging method. Nevertheless, only few data about sex-specific reference limits for right atrium (RA) dimensions are available. Transthoracic echocardiograph...
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Open AccessGalectin-3 for prediction of cardiac function compared to NT-proBNP in individuals with prediabetes and type 2 diabetes mellitus
Use of galectin-3 for assessing cardiac function in prediabetes and type 2 diabetes mellitus (T2DM) needs to be established. Within the Gutenberg Health Study cohort (N = 15,010, 35–74 years) patient character...
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Open AccessDistribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study
Glomerular filtration rate (GFR) declines with age by approx. 1 ml/min/m2 per year beginning in the third decade of life. At 70 years of age > 40 ml/min/m2 of GFR will be lost. Thus, factors affecting loss of GFR...
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Open AccessCost saving analysis of specialized, eHealth-based management of patients receiving oral anticoagulation therapy: Results from the thrombEVAL study
To evaluate the cost-saving of a specialized, eHealth-based management service (CS) in comparison to regular medical care (RMC) for the management of patients receiving oral anticoagulation (OAC) therapy. Cost...
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Open AccessInflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort
Depression has been associated with increased inflammation. However, only few large-scale, prospective studies have evaluated whether inflammation leads to new cases of depression and whether this association ...
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Open AccessSex-dependent associations of low birth weight and suicidal ideation in adulthood: a community-based cohort study
Low birth weight (LBW; < 2,500 g) has been identified as a risk factor for adverse mental health outcomes over the life span. However, little is known about the association of LBW and suicidal ideation in midd...
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Open AccessThe association of chronic anxiousness with cardiovascular disease and mortality in the community: results from the Gutenberg Health Study
In a large German community sample of adults, we investigated the association of chronic anxiousness with cardiovascular disease and mortality. Self-reported anxiousness from 11,643 German adults between 40 an...
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Open AccessAssociation between medicated obstructive pulmonary disease, depression and subjective health: results from the population-based Gutenberg Health Study
Medicated obstructive pulmonary disease (asthma or COPD) has been associated with depression. Yet, there is little knowledge of the interplay of contributing social, biological, behavioral and psychological fa...
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Open AccessCourse of depressive symptoms in men and women: differential effects of social, psychological, behavioral and somatic predictors
In this study, we aimed to identify the most important and sex-specific social, psychological, behavioral and somatic predictors of recurrent depressive symptoms. Data was obtained at two measurement points wi...
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Open AccessTranscriptome 3′end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma
Diversification at the transcriptome 3′end is an important and evolutionarily conserved layer of gene regulation associated with differentiation and dedifferentiation processes. Here, we identify extensive tra...
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Open AccessRelation between Arterial Stiffness and Markers of Inflammation and Hemostasis – Data from the Population-based Gutenberg Health Study
The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness in...
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Open AccessAge-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis
Previous reports have investigated the impact of age on D-Dimer testing in elderly individuals with suspected deep vein thrombosis (DVT), but data on the age-related diagnostic value of D-dimer in a sample cov...
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Open AccessMean Platelet Volume and Arterial Stiffness – Clinical Relationship and Common Genetic Variability
Vessel wall stiffening is an important clinical parameter, but it is unknown whether platelets, key elements in the pathogenesis of arterial thrombosis, are associated with arterial stiffness. The present stud...
