4 Result(s)
within
Karin Straathof
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessPediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity
Immune-therapy is an attractive alternative therapeutic approach for targeting central nervous system (CNS) tumors and the constituency of the Tumor Immune Microenvironment (TIME) likely to predict patient res...
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Article
Open AccessIntratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain cancer, for which effective therapies are urgently needed. Chimeric antigen receptor (CAR)-based immunotherapy represents a...
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Article
Open AccessSomatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
Malignant rhabdoid tumour (MRT) is an often lethal childhood cancer that, like many paediatric tumours, is thought to arise from aberrant fetal development. The embryonic root and differentiation pathways unde...
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Article
Open AccessSingle cell derived mRNA signals across human kidney tumors
Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular orig...
