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Star Trek
The STAR family has an extremely diverse role during development and in RNA metabolism. We have concentrated on QKI as an example of this pleiotropic activity and also presented some new data on the role of it...
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Article
Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development
To rapidly identify genes required for early vertebrate development, we are carrying out a large-scale, insertional mutagenesis screen in zebrafish, using mouse retroviral vectors as the mutagen. We will obtai...
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Article
Genomic organization and expression analysis of the mouse qkI locus
qkI, encoding a KH domain-containing RNA binding protein, has been isolated as a candidate gene for the mouse neurological mutation quaking. Here, we describe detailed studies on its genomic structure and expres...
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Article
Genetic map** of 10 microsatellites in the t complex region of mouse Chromosome 17
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Article
Mouse chromosome 17
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Article
The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins
The mouse quaking gene, essential for nervous system myelination and survival of the early embryo has been positionally cloned. Its sequence implies that the locus encodes a multifunctional gene used in a specifi...
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Article
Mouse chromosome 17
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Article
Map positions of four dinucleotide repeats in the mouse t complex
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Article
Mouse Chromosome 17
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Article
Molecular organization of theD-Qa region oft-haplotypes suggests that recombination is an important mechanism for generating genetic diversity of the major histocompatibility complex
We have determined the molecular maps of theH-2D andQa regions of thet-complex haplotypest l2 andt w5 ...
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Mouse chromosome 17
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Article
In memoriam Dorothea Bennett 1929–1990
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Article
Intra-H-2 recombination in t haplotypes shows a hot spot and close linkage of l tw5 to H-2K
The embryonic lethal mutation in the t w5 haplotype is known to map near the H-2K region of the mouse major histocompatibility complex. Additional data obtained by classical ge...
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Article
Murine T-haplotypes: Developments in 1983
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Article
Inversion in the H–2 complex of t-haplotypes in mice
Mouse t-haplotypes demonstrate strong linkage disequilibrium between t-lethal genes and specific H–2 types, presumably a result of recombination suppression between t and normal chromosomes1. The observation of f...
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Article
Relationship of the murine T-haplotypes and the H-2 complex
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Article
Reexpression of a T/t-complex antigen (t12) in thymocyte × embryonal carcinoma cell hybrids
Hybrids between PCC4 aza 1 teratocarcinoma cells and thymocytes from an adult +/t12 mouse are phenotypically embryonal carcinoma cells. They express the t12 antigen and do not express detectable H-2 antigens. Nor...
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Article
Recombination suppression of mouse t-haplotypes due to chromatin mismatching
We show here that recombination occurs at the normal rate in compound female mice containing two different complementing lethal haplotypes (th17/tw12 where there is a long stretch of homologous t-mutant chromatin...
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Article
Molecular analysis of the genetic relationship of trans interacting factors at the T/t complex
The T/t complex is an extensive genetic region proximal to the H–2 complex on mouse chromosome 17, with multiple effects on embryonic development, spermatogenesis and recombination1–3. Recently, two-dimensional g...
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Article
Relationship of F9 antigen and genes of theT/t complex
Serological studies relating F9 antigen of embryonal carcinoma cells to \( + ^{t^{12} } \) at the murineT/t complex ...