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Article
Polynomial Excitation Current Compensation Control for Dead Zone and Hysteresis of Three-way Proportional Pressure Reducing Valve
In this paper, aiming at the phenomenon that the dead zone and hysteresis of three-way proportional pressure reducing valve (TPPRV) will seriously affect the control accuracy of construction machinery, a polyn...
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Article
Lactiplantibacillus plantarum RS20D Alleviates Male Reproductive Toxicity Induced by Pubertal Exposure to Di-n-butyl Phthalate and Mono-n-butyl Phthalate
Phthalate acid esters (PAEs) and their metabolites, such as di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP), are known to cause male reproductive damage. Lactiplantibacillus plantarum RS20D has demons...
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Article
Open AccessGBA1 as a risk gene for osteoporosis in the specific populations and its role in the development of Gaucher disease
Osteoporosis and its primary complication, fragility fractures, contribute to substantial global morbidity and mortality. Gaucher disease (GD) is caused by glucocerebrosidase (GBA1) deficiency, leading to skel...
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Article
Microstructure and Mechanical Behavior of Mg-Based Bimetal Plates with High Formability Sleeve by Co-extrusion
In this study, microstructure and mechanical behavior of two types of Mg-based bimetal plates with a high formability sleeve were systematically studied, with a great emphasis on the effect of the interface ch...
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Article
Open AccessTransformation to small cell lung cancer is irrespective of EGFR and accelerated by SMAD4-mediated ASCL1 transcription independently of RB1 in non-small cell lung cancer
Histological transformation to small cell lung cancer (SCLC) has been identified as a mechanism of TKIs resistance in EGFR-mutant non-small cell lung cancer (NSCLC). We aim to explore the prevalence of transforma...
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Article
Associations of prenatal exposure to bisphenols with BMI growth trajectories in offspring within the first two years: evidence from a birth cohort study in China
Prenatal bisphenol exposure has been reported to be associated with lower birth weight and obesity-related indicators in early childhood. These findings warrant an investigation of the relationship between pre...
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Article
Anti-CD79b/CD3 bispecific antibody combined with CAR19-T cells for B-cell lymphoma treatment
CD19 CAR-T (chimeric antigen receptor-T) cell immunotherapy achieves a remission rate of approximately 70% in recurrent and refractory lymphoma treatment. However, the loss or reduction of CD19 antigen on the ...
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Article
Open AccessZika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids
Zika virus (ZIKV) infection during pregnancy threatens pregnancy and fetal health. However, the infectivity and pathological effects of ZIKV on placental trophoblast progenitor cells in early human embryos rem...
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Article
1D/2D composite subnanometer channels for ion transport: The role of confined water
As a mass transport media, water is an alternative of organic solvent applied in rechargeable batteries, due to its unique properties, including fast ionic migration, easy-processibility, economic/environmenta...
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Article
NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1
Gliomas and their surrounding microenvironment constantly interact to promote tumorigenicity, yet the underlying posttranscriptional regulatory mechanisms that govern this interplay are poorly understood.
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Article
Occurrence and ecological risk assessment of 16 phthalates in surface water of the mainstream of the Yangtze River, China
Phthalic acid esters (PAEs), a class of typical endocrine disruptors, have received considerable attention due to their widespread applications and adverse effects on biological health. In this study, 30 water...
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Article
Production of MSTN knockout porcine cells using adenine base-editing-mediated exon skip**
Gene-knockout pigs have important applications in agriculture and medicine. Compared with CRISPR/Cas9 and cytosine base editing (CBE) technologies, adenine base editing (ABE) shows better safety and accuracy i...
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Article
O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma
Aberrantly elevated O-GlcNAcylation level is commonly observed in human cancer patients, and has been proposed as a potential therapeutic target. Speckle-type POZ protein (SPOP), an important substrate adaptor...
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Article
Upregulation of TUBG1 expression promotes hepatocellular carcinoma development
Tubulin γ-1 (TUBG1) is a highly conserved component of the centrosome and its deregulation is involved in the development of several types of cancer. However, the role of TUBG1 in hepatocellular carcinoma (HCC) r...
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Article
Damage evolution and strength attenuation characteristics of carbonaceous slate under low velocity dynamic impact
Rock is subjected to impact loading during tunnel and subsurface engineering. For understanding the damage evolution of rock under dynamic impact, mechanical research was performed on the carboniferous slate s...
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Article
Open AccessInhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma
The patients with relapsed and refractory diffuse large B-cell lymphoma (DLBCL) have poor prognosis, and a novel and effective therapeutic strategy for these patients is urgently needed. Although ubiquitin-spe...
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Article
Open AccessCorrection: Changes in the humoral immunity response in SARS-CoV-2 convalescent patients over 8 months
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Article
Intrinsically elastic and self-healing luminescent polyisoprene copolymers formed via covalent bonding and hydrogen bonding design
Although development of soft and stretchable materials exhibiting semiconducting functions, such as luminescent or electronic properties, has received growing interest, development of intrinsically self-healin...
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Article
Open AccessKnockdown of RAD51AP1 suppressed cell proliferation and invasion in esophageal squamous cell carcinoma
Esophageal cancer is a common malignant tumor of digestive tract with esophageal squamous cell carcinoma (ESCC) being the main histological subtype. This study aimed to identify potential hub gene associated w...
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Article
Novel recombinant human thyroid-stimulating hormone in aiding postoperative assessment of patients with differentiated thyroid cancer—phase I/II study
Thyroid hormone withdrawal (THW) inevitably induced hypothyroidism in patients with differentiated thyroid cancer (DTC), and we aimed to evaluate the safety and efficacy of a novel recombinant human thyroid-st...
