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Article
Open AccessExploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder
Major depressive disorder (MDD) is associated with interoceptive processing dysfunctions, but the molecular mechanisms underlying this dysfunction are poorly understood. This study combined brain neuronal-enri...
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Article
Open AccessElevated serum leptin is associated with attenuated reward anticipation in major depressive disorder independent of peripheral C-reactive protein levels
Major depressive disorder (MDD) is associated with immunologic and metabolic alterations linked to central processing dysfunctions, including attenuated reward processing. This study investigated the associati...
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Article
Open AccessPsychiatric symptoms are not associated with circulating CRP concentrations after controlling for medical, social, and demographic factors
Elevated serum concentrations (>3 mg/L) of the acute-phase protein, C-reactive protein (CRP), is used as a clinical marker of inflammation and is reported to be a strong risk factor for cardiovascular disease....
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Article
Open AccessNeuronally-enriched exosomal microRNA-27b mediates acute effects of ibuprofen on reward-related brain activity in healthy adults: a randomized, placebo-controlled, double-blind trial
This double-blind, randomized, within-subjects design evaluated whether acute administration of an anti-inflammatory drug modulates neuron-specific, inflammation-modulating microRNAs linked to macroscopic chan...
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Article
Open AccessAssociation between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension
Human cytomegalovirus (HCMV) is a neurotropic herpes virus known to cause neuropathology in patients with impaired immunity. Previously, we reported a reduction in the gray matter volume (GMV) of several brain...
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Article
Open AccessReplicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder
Major depressive disorder (MDD) is associated with reductions in white matter microstructural integrity as measured by fractional anisotropy (FA), an index derived from diffusion tensor imaging (DTI). The neur...
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Article
Appetite changes reveal depression subgroups with distinct endocrine, metabolic, and immune states
There exists little human neuroscience research to explain why some individuals lose their appetite when they become depressed, while others eat more. Answering this question may reveal much about the various ...
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Article
How the Brain Wants What the Body Needs: The Neural Basis of Positive Alliesthesia
Discontinuing unhealthy behaviors, such as overeating or drug use, depends upon an individual’s ability to overcome the influence of environmental reward cues. The strength of that influence, however, varies g...
