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  1. Article

    Open Access

    Real-world study of afatinib in first-line or re-challenge settings for patients with EGFR mutant non-small cell lung cancer

    Afatinib, a second-generation epidermal growth factor receptor (EGFR)—tyrosine kinase inhibitor (TKI) for mutant non-small cell lung cancer (NSCLC), was approved in Japan in 2014. This study evaluated clinical...

    Hisashi Tanaka, Kageaki Taima, Masamichi Itoga, Yoshiko Ishioka in Medical Oncology (2019)

  2. Article

    Open Access

    A phase I study of afatinib for patients aged 75 or older with advanced non-small cell lung cancer harboring EGFR mutations

    This phase I trial was conducted to determine the maximum tolerated dose (MTD) and recommended dose of afatinib for phase II trial in elderly patients with advanced non-small cell lung cancer (NSCLC) harboring...

    Hisashi Tanaka, Kageaki Taima, Yoshihito Tanaka, Masamichi Itoga in Medical Oncology (2018)

  3. Article

    Open Access

    A single-arm phase II study of nab-paclitaxel for patients with chemorefractory non-small cell lung cancer

    We aimed to evaluate the efficacy and safety of nab-paclitaxel in patients with refractory advanced non-small cell lung cancer who failed previous chemotherapy.

    Hisashi Tanaka, Kageaki Taima, Takeshi Morimoto, Yoshihito Tanaka in BMC Cancer (2017)

  4. Article

    Open Access

    A case of lung adenocarcinoma harboring EGFR mutation and EML4-ALKfusion gene

    Lung cancer is the leading cause of cancer-related death worldwide. Epidermal growth factor receptor (EGFR) - tyrosine kinase inhibitor (TKI) is used for the patients with EGFR-mutant lung cancer. Recently, phase...

    Hisashi Tanaka, Akihito Hayashi, Takeshi Morimoto, Kageaki Taima in BMC Cancer (2012)