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Article

Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development

We examined genetic and epigenetic changes that occur during disease progression from indolent to aggressive forms of chronic lymphocytic leukemia (CLL) using serial samples from 27 patients. Analysis of DNA m...

E N Smith, E M Ghia, C M DeBoever, L Z Rassenti, K Jepsen, K-A Yoon… in Blood Cancer Journal (2015)