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Article
Pyrazine Derivatives—Versatile Scaffold
Pyrazines are important class of pharmacophores because of their versatility in pharmacological activity. Pyrazines are among the most widely known heterocyclic compounds those can be isolated from natural sou...
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Article
Open AccessSystematic review of the use of translated patient-reported outcome measures in cancer trials
Patient-reported outcomes (PROs) are used in clinical trials to assess the effectiveness and tolerability of interventions. Inclusion of participants from different ethnic backgrounds is essential for generali...
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Article
Open AccessExperimental Validation of an ITAP Numerical Model and the Effect of Implant Stem Stiffness on Bone Strain Energy
The Intraosseous Transcutaneous Amputation Prosthesis (ITAP) offers transfemoral amputees an ambulatory method potentially reducing soft tissue complications seen with socket and stump devices. This study vali...
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Article
Protein Kinase CK2 in Health and Disease
Elevated levels of protein kinase CK2 (formerly casein kinase 2 or II) have long been associated with increased cell growth and proliferation both in normal and cancer cells. The ability of CK2 to also act as ...
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Article
Circadian variation of serum testosterone in the adult male rat with a late morning acrophase
Serum testosterone concentrations were measured in adult male Sprague-Dawley rats. A significant circadian testosterone rhythm (p<0.01) was found with peak values at 10.00 and 13.00 h.