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    Article

    The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272

    Mutations in the ERBB2 gene were recently found in approximately 2% of primary non-small cell lung cancer (NSCLC) specimens; however, little is known about the functional consequences and the relevance to respons...

    Y Minami, T Shimamura, K Shah, T LaFramboise, K A Glatt, E Liniker, C L Borgman… in Oncogene (2007)