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Article
Activation of ERK and suppression of calcineurin are interacting mechanisms of cardioprotection afforded by δ-opioid receptor activation
The aim of this study was to examine possible interactions of ERK and calcineurin in cardioprotection afforded by δ-opioid receptor stimulation. Infarction was induced in rat hearts by 20-min coronary occlusio...
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Article
Interruption of signal transduction between G protein and PKC-ε underlies the impaired myocardial response to ischemic preconditioning in postinfarct remodeled hearts
We have recently shown that the protective mechanism of ischemic preconditioning (PC) is impaired in the myocardium that survived infarction and underwent postinfarct ventricular remodeling. In this study, we ...
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Chapter
Bradykinin and Preconditioning Against Infarction
Bradykinin is a peptide consisting of nine amino acids, which is generated by the plasma kallikrein-kinin system as well as the glandular (tissue) kallikrein-kinin system and plasma aminopeptidase (Fig. 11-1)....