27 Result(s)
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Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC–MS based untargeted metabolomics practitioners
The metabolomics quality assurance and quality control consortium (mQACC) evolved from the recognized need for a community-wide consensus on improving and systematizing quality assurance (QA) and quality contr...
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In memory of Michael J. O. Wakelam (1955–2020): a pioneer in lipid signalling and lipidomics
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Open AccessA model for determining cardiac mitochondrial substrate utilisation using stable 13C-labelled metabolites
Relative oxidation of different metabolic substrates in the heart varies both physiologically and pathologically, in order to meet metabolic demands under different circumstances. 13C labelled substrates have bec...
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Italian cohort of patients affected by inflammatory bowel disease is characterised by variation in glycerophospholipid, free fatty acids and amino acid levels
Inflammatory bowel disease is a group of pathologies characterised by chronic inflammation of the intestine and an unclear aetiology. Its main manifestations are Crohn’s disease and ulcerative colitis. Current...
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Open AccessKniMet: a pipeline for the processing of chromatography–mass spectrometry metabolomics data
Data processing is one of the biggest problems in metabolomics, given the high number of samples analyzed and the need of multiple software packages for each step of the processing workflow.
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Open AccessmassPix: an R package for annotation and interpretation of mass spectrometry imaging data for lipidomics
Mass spectrometry imaging (MSI) experiments result in complex multi-dimensional datasets, which require specialist data analysis tools.
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Open AccessThe translation of lipid profiles to nutritional biomarkers in the study of infant metabolism
Links between early life exposures and later health outcomes may, in part, be due to nutritional programming in infancy. This hypothesis is supported by observed long-term benefits associated with breastfeeding, ...
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Open AccessComputational tools and workflows in metabolomics: An international survey highlights the opportunity for harmonisation through Galaxy
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A clustering-based preprocessing method for the elimination of unwanted residuals in metabolomic data
The metabolome of a biological system is affected by multiple factors including factor of interest (e.g. metabolic perturbation due to disease) and unwanted factors or factors which are not primarily the focus...
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Open AccessA targeted metabolomics assay for cardiac metabolism and demonstration using a mouse model of dilated cardiomyopathy
Metabolomics can be performed either as an ‘open profiling’ tool where the aim is to measure, usually in a semi-quantitative manner, as many metabolites as possible or perform ‘closed’ or ‘targeted’ analyses w...
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Erratum to: COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access
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Open AccessCOordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access
Metabolomics has become a crucial phenoty** technique in a range of research fields including medicine, the life sciences, biotechnology and the environmental sciences. This necessitates the transfer of exp...
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Open AccessThe development and validation of a fast and robust dried blood spot based lipid profiling method to study infant metabolism
Early life exposures and metabolic programming are associated with later disease risk. In particular lipid metabolism is thought to play a key role in the development of the metabolic syndrome and insulin resi...
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Metabolite identification: are you sure? And how do your peers gauge your confidence?
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NMR-based metabolomics in human disease diagnosis: applications, limitations, and recommendations
Metabolomics is a dynamic and emerging research field, similar to proteomics, transcriptomics and genomics in affording global understanding of biological systems. It is particularly useful in functional genom...
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Open AccessIncreased unsaturation of lipids in cytoplasmic lipid droplets in DAOY cancer cells in response to cisplatin treatment
Increases in 1H nuclear magnetic resonance spectroscopy (NMR) visible lipids are a well-documented sign of treatment response in cancers. Lipids in cytoplasmic lipid droplets (LDs) are the main contributors to th...
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Obesity in mice with adipocyte-specific deletion of clock component Arntl
A molecular mechanism in the brain and individual tissues allows mammals to adapt to a 24-hour clock. Garret FitzGerald and colleagues now show that genetic deletion of one member of this pathway specifically ...
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Open AccessMetaboLights: towards a new COSMOS of metabolomics data management
Exciting funding initiatives are emerging in Europe and the US for metabolomics data production, storage, dissemination and analysis. This is based on a rich ecosystem of resources around the world, which has ...
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Ask not what data standards can do for you but what you can do for data standards: a personal view of reporting standardisation in metabolomic experiments
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A single enteral feed prior to the commencement of parenteral nutrition ameliorates the incidence of steatosis in parenterally fed neonatal piglets
Total parenteral nutrition (TPN) in neonates is associated with liver dysfunction. The initial post-partum enteral feed plays a key role in establishing post-partum metabolic regulation. Therefore absence of e...
