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  1. Article

    Open Access

    Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci

    Genetic, lifestyle, and environmental factors can lead to perturbations in circulating lipid levels and increase the risk of cardiovascular and metabolic diseases. However, how changes in individual lipid spec...

    Eric L. Harshfield, Eric B. Fauman, David Stacey, Dirk S. Paul… in BMC Medicine (2021)

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  2. Article

    Insulin resistance induced by growth hormone is linked to lipolysis and associated with suppressed pyruvate dehydrogenase activity in skeletal muscle: a 2 × 2 factorial, randomised, crossover study in human individuals

    Growth hormone (GH) causes insulin resistance that is linked to lipolysis, but the underlying mechanisms are unclear. We investigated if GH-induced insulin resistance in skeletal muscle involves accumulation o...

    Astrid J. Hjelholt, Evelina Charidemou, Julian L. Griffin… in Diabetologia (2020)

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    Article

    Metabolomics as a tool for cardiac research

    Metabolomics is emerging as a powerful tool for the investigation of the molecular mechanisms of cardiovascular disease, including atherosclerosis, ischemia, myocardial infarction, and heart failure. In this R...

    Julian L. Griffin, Helen Atherton, John Shockcor, Luigi Atzori in Nature Reviews Cardiology (2011)