8 Result(s)
within
Juhyun Kim
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessMicroglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11.2 duplication
Adolescent cannabis use increases the risk for cognitive impairments and psychiatric disorders. Cannabinoid receptor type 1 (Cnr1) is expressed not only in neurons and astrocytes, but also in microglia, which ...
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Article
Ptbp1 deletion does not induce astrocyte-to-neuron conversion
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Article
Open AccessDynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes
Introduction of synthetic circuits into microbes creates competition between circuit and host genes for shared cellular resources, such as ribosomes. This can lead to the emergence of unwanted coupling between...
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Article
Correction: Corrigendum: Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep
Nature 548, 582–587 (2017); doi:10.1038/nature23663 In this Letter, the surname of author Vassilis Pachnis was misspelled as ‘Pachinis’. The original Letter has been corrected online.
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Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep
GABAergic Lhx6+ neurons in the ventral zona incerta promote both rapid eye movement and non-rapid eye movement sleep and inhibit the activity of wake-promoting GABAergic and Hcrt+ neurons of the lateral hypothala...
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Article
Open AccessCell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog
A hexanucleotide repeat expansion in the C9orf72 gene is the most common cause of inherited forms of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Both loss-of-function and gain-of-function m...
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Article
Open AccessMemory programming in CD8+ T-cell differentiation is intrinsic and is not determined by CD4 help
CD8+ T cells activated without CD4+ T-cell help are impaired in memory expansion. To understand the underlying cellular mechanism, here we track the dynamics of helper-deficient CD8+ T-cell response to a minor hi...
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Open AccessTargeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through MicroRNA Regulation
Hepatocellular carcinoma (HCC) has a high fatality rate and limited therapeutic options with side effects and low efficacy. Here, we proposed a new anti-HCC approach based on cancer-specific post-transcription...
