8 Result(s)
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Ju Hyun Lee
Biomedicine
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Article
Open AccessFaulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific transgeni...
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Article
Open AccessCell-line dependency in cerebral organoid induction: cautionary observations in Alzheimer’s disease patient-derived induced pluripotent stem cells
The cerebral organoid (CO) model has been used in the study of various neurodegenerative diseases owing to its physiological implications. However, the CO model may only be representative of certain clinical f...
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Article
Production of human spinal-cord organoids recapitulating neural-tube morphogenesis
Human spinal-cord-like tissues induced from human pluripotent stem cells are typically insufficiently mature and do not mimic the morphological features of neurulation. Here, we report a three-dimensional cult...
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Article
Transcriptome dynamics of alternative splicing events revealed early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma cells
Methylparaben is most frequently used as an antimicrobial preservative in pharmaceuticals and foods. Methylparaben has been subjected to toxicological studies owing to the increasing concern regarding its poss...
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Article
Preparation of Sustained Release Tablet with Minimized Usage of Glyceryl Behenate Using Post-Heating Method
The purpose of this study was to prepare sustained release (SR) matrix tablets using a direct compression incorporated with a post-heating process. Allopurinol was selected due to the water-soluble property an...
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Article
Open AccessSuppression of the ERK–SRF axis facilitates somatic cell reprogramming
The molecular mechanism underlying the initiation of somatic cell reprogramming into induced pluripotent stem cells (iPSCs) has not been well described. Thus, we generated single-cell-derived clones by using a...
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Article
Immunohistochemical localization of sodium-dependent l-ascorbic acid transporter 1 protein in rat kidney
Recently, two l-ascorbic acid transporters were identified; sodium-dependent vitamin C transporter (SVCT) 1 and SVCT2. The previous study suggested that SVCT protein might be present on the apical membrane in the...
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Article
Comparisons of the NACP Self-Oligomerizations Induced by Aβ25-35 in the Presence of Dicyclohexylcarbodiimide and N-(Ethoxycarbonyl)-2-Ethoxy-1,2-Dihydroquinoline
NACP, the precursor protein of the non-amyloid β/A4 protein (Aβ) component of Alzheimer's disease (AD) amyloid, also known as α-synuclein was shown to undergo self-oligomerization only in the presence of a mod...
