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  1. Article

    Open Access

    Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model

    Tuberculosis BCG vaccination induced non-specific protective effects in humans led to postulate the concept of trained immunity (TRAIM) as an innate type of immune mechanism that triggered by a pathogen, prote...

    Rosa Casais, Natalia Iglesias, Iker A. Sevilla, Joseba M. Garrido in Veterinary Research (2024)

  2. Article

    Open Access

    Mycobacterium tuberculosis extracellular vesicle-associated lipoprotein LpqH as a potential biomarker to distinguish paratuberculosis infection or vaccination from tuberculosis infection

    Both bovine tuberculosis (TB) and paratuberculosis (PTB) are serious and widespread bacterial infections affecting many domestic and wild animal species. However, current vaccines do not confer complete protec...

    Ainhoa Palacios, Leticia Sampedro, Iker A. Sevilla, Elena Molina in BMC Veterinary Research (2019)

  3. Article

    Open Access

    Different lesion distribution in calves orally or intratracheally challenged with Mycobacterium bovis: implications for diagnosis

    Animal tuberculosis (TB) remains a major problem in some countries despite the existence of control programmes focused mainly on cattle. In this species, aerogenous transmission is accepted as the most frequen...

    Miriam Serrano, Iker A. Sevilla, Miguel Fuertes, Mariví Geijo in Veterinary Research (2018)

  4. Article

    Open Access

    Vaccination sequence effects on immunological response and tissue bacterial burden in paratuberculosis infection in a rabbit model

    Paratuberculosis (PTB), a chronic granulomatous enteritis produced by Mycobacterium avium subspecies paratuberculosis (MAP), is considered as one of the diseases with the highest economic impact in the ruminant i...

    Rakel Arrazuria, Elena Molina, Joseba M. Garrido, Valentín Pérez in Veterinary Research (2016)

  5. Article

    Open Access

    Detection of Mycobacterium avium subspecies in the gut associated lymphoid tissue of slaughtered rabbits

    Rabbits are susceptible to infection by different species of the genus Mycobacterium. Particularly, development of specific lesions and isolation of Mycobacterium avium subsp. avium and Mycobacterium avium subsp....

    Rakel Arrazuria, Iker A Sevilla, Elena Molina, Valentín Pérez in BMC Veterinary Research (2015)

  6. Article

    Open Access

    Oral re-vaccination of Eurasian wild boar with Mycobacterium bovis BCG yields a strong protective response against challenge with a field strain

    Field vaccination trials with Mycobacterium bovis BCG, an attenuated mutant of M. bovis, are ongoing in Spain, where the Eurasian wild boar (Sus scrofa) is regarded as the main driver of animal tuberculosis (TB)....

    Christian Gortazar, Beatriz Beltrán-Beck, Joseba M Garrido in BMC Veterinary Research (2014)

  7. Article

    Open Access

    Experimental infection of lambs with C and S-type strains of Mycobacterium avium subspecies paratuberculosis: immunological and pathological findings

    The two main genotypes of recognized isolates of Mycobacterium avium subsp. paratuberculosis (Map) are cattle (C) and sheep (S) strains. An experimental infection was conducted to establish the effect of Map stra...

    Miguel Fernández, Julio Benavides, Iker A Sevilla, Miguel Fuertes in Veterinary Research (2014)

  8. Article

    Open Access

    Effects of vaccination against paratuberculosis on tuberculosis in goats: diagnostic interferences and cross-protection

    Most countries carrying out campaigns of bovine tuberculosis (TB) eradication impose a ban on the use of mycobacterial vaccines in cattle. However, vaccination against paratuberculosis (PTB) in goats is often ...

    Bernat Pérez de Val, Miquel Nofrarías, Sergio López-Soria in BMC Veterinary Research (2012)

  9. Article

    Open Access

    Atypical/Nor98 scrapie in the Basque Country: a case report of eight outbreaks

    Since 2002, an active surveillance program for transmissible spongiform encephalopathy in small ruminants in European Union countries allowed identification of a considerable number of atypical cases with simi...

    Ana B Rodríguez-Martínez, Joseba M Garrido, Sonia Maza in BMC Veterinary Research (2010)