6 Result(s)
-
Article
Open AccessPost-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis
Neural stem cells (NSCs) in the adult murine subependymal zone balance their self-renewal capacity and glial identity with the potential to generate neurons during the lifetime. Adult NSCs exhibit lineage prim...
-
Article
Open AccessThe rates of adult neurogenesis and oligodendrogenesis are linked to cell cycle regulation through p27-dependent gene repression of SOX2
Cell differentiation involves profound changes in global gene expression that often has to occur in coordination with cell cycle exit. Because cyclin-dependent kinase inhibitor p27 reportedly regulates prolife...
-
Article
MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin
The identification of mechanisms that maintain stem cell niche architecture and homeostasis is fundamental to our understanding of tissue renewal and repair. Cell adhesion is a well-characterized mechanism for...
-
Article
Transcriptional repression of Bmp2 by p21Waf1/Cip1 links quiescence to neural stem cell maintenance
The self renewal and long-term maintenance of neural stem cells (NSCs) is related to how quickly they pass through the cell cycle. Here the authors describe a new role for the cyclin-dependent kinase inhibitor...
-
Article
Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis
Life-long neurogenesis is known to occur in some areas of the mammalian adult brain, including in the subventricular zone (SVZ), where interaction between neural precursor cells and resident astrocytes can pro...
-
Article
Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone
Notch signaling is essential for the maintenance of adult neural stem cells in vivo. Here, Andreu-Agulló and colleagues show that PEDF, released from endothelial cells, enhances Notch signaling in the mouse subep...
