7 Result(s)
within
Joost Westerhout
English
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Article
Open AccessTowards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment
With an increasing need to incorporate new approach methodologies (NAMs) in chemical risk assessment and the concomitant need to phase out animal testing, the interpretation of in vitro assay readouts for quan...
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Article
Open AccessAbstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Article
Open AccessFood allergy population thresholds: DBPCFC data for rice, kiwi, apple, peach, carrot, maize, tomato, and other less common allergenic foods
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Chapter
Ussing Chamber
The Ussing chamber system is named after the Danish zoologist Hans Ussing, who invented the device in the 1950s to measure the short-circuit current as an indicator of net ion transport taking place across fro...
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Article
Open AccessThe impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid
In the development of central nervous system (CNS)-targeted drugs, the prediction of human CNS target exposure is a big challenge. Cerebrospinal fluid (CSF) concentrations have often been suggested as a ‘good ...
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Article
Open AccessHuman embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach
Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often manifest themselves in functional deficits that are not necessarily based on cell death, but rather on minor changes relatin...
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Article
Open AccessPhysiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats
One of the major challenges in the development of central nervous system (CNS)-targeted drugs is predicting CNS exposure in human from preclinical data. In this study, we present a methodology to investigate b...
