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  1. Article

    Open Access

    HM71224, a selective Bruton’s tyrosine kinase inhibitor, attenuates the development of murine lupus

    Systemic lupus erythematosus (SLE) is associated with B cell hyperactivity, and lupus nephritis (LN), in particular, is promoted by the production of autoantibodies and immune complex deposition. Bruton’s tyro...

    Yu-Yon Kim, Ki Tae Park, Sun Young Jang, Kyu Hang Lee… in Arthritis Research & Therapy (2017)

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  2. Article

    Open Access

    HM71224, a novel Bruton’s tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis

    Bruton’s tyrosine kinase (Btk) is critical for activation of B cells and myeloid cells. This study aimed to characterize the effects of HM71224, a novel Btk inhibitor, both in vitro and in a mouse model of experi...

    ** Kyun Park, Joo-Yun Byun, Ji Ah Park, Yu-Yon Kim… in Arthritis Research & Therapy (2016)

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