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Article

Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection

The selective Bruton tyrosine kinase (BTK) inhibitor poseltinib has been shown to inhibit the BCR signal transduction pathway and cytokine production in B cells (Park et al. Arthritis Res. Ther. 18, 91, ...

Joo-Yun Byun, Yi T. Koh, Sun Young Jang, Jennifer W. Witcher… in Scientific Reports (2021)