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  1. No Access

    Article

    Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

    Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 6...

    Niamh Mullins, Andreas J. Forstner, Kevin S. O’Connell, Brandon Coombes… in Nature Genetics (2021)

  2. No Access

    Article

    Genome-wide association study identifies 30 loci associated with bipolar disorder

    Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 v...

    Eli A. Stahl, Gerome Breen, Andreas J. Forstner, Andrew McQuillin… in Nature Genetics (2019)

  3. No Access

    Article

    Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

    Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene ...

    Mengzhen Liu, Yu Jiang, Robbee Wedow, Yue Li, David M. Brazel, Fang Chen… in Nature Genetics (2019)

  4. No Access

    Article

    Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

    Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,45...

    Naomi R. Wray, Stephan Ripke, Manuel Mattheisen, Maciej Trzaskowski… in Nature Genetics (2018)

  5. Article

    Open Access

    A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder

    The nature and underlying mechanisms of the observed increased vulnerability to posttraumatic stress disorder (PTSD) in women are unclear.

    Renato Polimanti, Ananda B. Amstadter, Murray B. Stein, Lynn M. Almli… in Genome Medicine (2017)

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  6. No Access

    Article

    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

    Ken Ong and colleagues report meta-analysis of 32 genome-wide association studies for age at menarche. They identify 30 loci newly associated with age at menarche, including four that were previously associate...

    Cathy E Elks, John R B Perry, Patrick Sulem, Daniel I Chasman… in Nature Genetics (2010)

  7. No Access

    Article

    Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28

    Linkage disequilibrium (LD), or the non-random association of alleles, is poorly understood in the human genome1. Population genetic theory suggests that LD is determined by the age of the markers, population his...

    Patricia Taillon-Miller, Irma Bauer-Sardiña, Nancy L. Saccone… in Nature Genetics (2000)