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  1. No Access

    Chapter

    Estradiol Inhibition of Expression of the Human Glycoprotein Hormone α-Subunit Gene Through an ERE-Independent Mechanism

    The α-subunit comprises one-half of all glycoprotein hormones. Expression of the α-subunit gene occurs in a variety of cell types (gonadotrophs, thyrotrophs, and syncytiotrophoblasts) and is regulated by a mul...

    Ruth A. Keri, Bogi Andersen, Giulia C. Kennedy… in Follicle Stimulating Hormone (1992)

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    Chapter and Conference Paper

    The α-Subunit of the Glycoprotein Hormones: Evolution of a Combinatorial Code for Placenta-Specific Expression

    Luteinizing hormone (LH), follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), andchorionic gonadotropin (CG) belong to a family of glycoprotein hormones. Each member is compose...

    Robin H. Pittman, John H. Nilson in Trophoblast Cells (1993)

  3. No Access

    Chapter

    Molecular Mechanisms Underlying Placenta- and Pituitary-Specific Expression of the Glycoprotein Hormone α-Subunit Gene

    All vertebrates synthesize three different pituitary glycoprotein hormones: luteinizing hormone (lutropin, LH), follicle stimulating hormone (folli-tropin, FSH), and thyroid stimulating hormone (thyrotropin, TSH)...

    John H. Nilson in Molecular Basis of Reproductive Endocrinology (1993)

  4. No Access

    Chapter and Conference Paper

    Expression by Transgenic Mouse Placenta of a Human Placental Hormone, the β-Subunit of Human Chorionic Gonadotropin

    Chorionic gonadotropin (CG) is a member of a family of glycoprotein hormones that includeslutropin (LH), follitropin, and thyrotropin. The 4 hormones are heterodimers with a common α-subunit and ...

    Brian L. Strauss, Robin H. Pittman, John H. Nilson, Irving Boime in Trophoblast Cells (1993)

  5. No Access

    Chapter

    LH Hypersecreting Mice: A Model for Ovarian Granulosa Cell Tumors

    Proper function of the ovary requires carefully orchestrated proliferation and differentiation of granulosa cells that respond dynamically to signals from LH and FSH, and a host of other paracrine and autocrin...

    Gabe E. Owens, Ruth A. Keri, John H. Nilson in Transgenic Models in Endocrinology (2001)

  6. No Access

    Article

    High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-α-subunit promoter/Simian virus 40 T-antigen fusion gene

    Transgenic (TG) mice expressing the Simian virus 40 T-antigen under the control of the murine inhibin-α promoter (Inhα/Tag) develop granulosa and Leydig cell tumors at the age of 5–6 months, with 100% penetrance....

    Maarit Mikola, Jukka Kero, John H Nilson, Ruth A Keri, Matti Poutanen… in Oncogene (2003)