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  1. No Access

    Article

    High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-α-subunit promoter/Simian virus 40 T-antigen fusion gene

    Transgenic (TG) mice expressing the Simian virus 40 T-antigen under the control of the murine inhibin-α promoter (Inhα/Tag) develop granulosa and Leydig cell tumors at the age of 5–6 months, with 100% penetrance....

    Maarit Mikola, Jukka Kero, John H Nilson, Ruth A Keri, Matti Poutanen… in Oncogene (2003)

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    Chapter

    LH Hypersecreting Mice: A Model for Ovarian Granulosa Cell Tumors

    Proper function of the ovary requires carefully orchestrated proliferation and differentiation of granulosa cells that respond dynamically to signals from LH and FSH, and a host of other paracrine and autocrin...

    Gabe E. Owens, Ruth A. Keri, John H. Nilson in Transgenic Models in Endocrinology (2001)