4 Result(s)
within
Joanna Kopecka
Biomedicine
Apoptosis
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Article
Open AccessMitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer
Solid tumors subjected to intermittent hypoxia are characterized by resistance to chemotherapy and immune-killing by effector T-lymphocytes, particularly tumor-infiltrating Vγ9Vδ2 T-lymphocytes. The molecular ...
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Article
Open AccessSKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma
The combination of pemetrexed and cisplatin remains the reference first-line systemic therapy for malignant pleural mesothelioma (MPM). Its activity is moderate because of tumor aggressiveness, immune-suppress...
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Article
Open AccessHypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
Solid tumors often grow in a micro-environment characterized by < 2% O2 tension. This condition, together with the aberrant activation of specific oncogenic patwhays, increases the amount and activity of the hypo...
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Article
Open AccessIncreasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer
Triple negative breast cancer (TNBC) easily develops resistance to the first-line drug doxorubicin, because of the high levels of the drug efflux transporter P-glycoprotein (Pgp) and the activation of pro-surv...
