4 Result(s)

Article

Mixed-lineage leukemia protein 2 suppresses ciliary assembly by the modulation of actin dynamics and vesicle transport

Primary cilia are critically involved in the coordination of diverse signaling pathways and ciliary defects are associated with a variety of human diseases. The past decades have witnessed great progress in th...

Yang Yang, Huijie Hao, **aofan Wu, Song Guo, Yang Liu, Jie Ran, Te Li… in Cell Discovery (2019)

Article

ASK1 controls spindle orientation and positioning by phosphorylating EB1 and stabilizing astral microtubules

Orientation and positioning of the mitotic spindle are involved in dictating cell division axis and cleavage site, and play important roles in cell fate determination and tissue morphogenesis. However, how spi...

Youguang Luo, Jie Ran, Songbo **e, Yunfan Yang, Jie Chen, Shanshan Li… in Cell Discovery (2016)

Article

Phosphoregulation of the dimerization and functions of end-binding protein 1

Jie Chen, Youguang Luo, Lixin Li, Jie Ran, **ncheng Wang, Siqi Gao… in Protein & Cell (2014)

Article

End-binding protein 1 stimulates paclitaxel sensitivity in breast cancer by promoting its actions toward microtubule assembly and stability

Paclitaxel is a microtubule-targeting agent widely used for the treatment of many solid tumors. However, patients show variable sensitivity to this drug, and effective diagnostic tests predicting drug sensitiv...

Youguang Luo, Dengwen Li, Jie Ran, Bing Yan, Jie Chen, **n Dong, Zhu Liu… in Protein & Cell (2014)