52 Result(s)

Article

ID1 expressing macrophages support cancer cell stemness and limit CD8⁺ T cell infiltration in colorectal cancer

Elimination of cancer stem cells (CSCs) and reinvigoration of antitumor immunity remain unmet challenges for cancer therapy. Tumor-associated macrophages (TAMs) constitute the prominant population of immune ce...

Shuang Shang, Chen Yang, Fei Chen, Ren-shen **ang, Huan Zhang… in Nature Communications (2023)

Article

A single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotype

Increasing evidence shows the African lineage Zika virus (ZIKV) displays a more severe neurovirulence compared to the Asian ZIKV. However, viral determinants and the underlying mechanisms of enhanced virulence...

Guang-Yuan Song, **ng-Yao Huang, Meng-Jiao He, Hang-Yu Zhou… in Nature Communications (2023)

Article

Relationship between body composition and pulmonary function in the general population—a cross-sectional study in Ningxia

Studies considering the relationship between non-obesity-related body composition and lung function are few; therefore, this study aimed to explore these correlations and effects. This cross-sectional study co...

Yang-yang Pi, Wen-xuan Hu, Zi-ming Jiao, Peng-yi Hou, Yu-hong Zhang… in Scientific Reports (2023)

Article

Adhesion-regulating molecule 1 (ADRM1) can be a potential biomarker and target for bladder cancer

Adhesion-regulating molecule 1 (ADRM1) has been implicated in tumor development, yet its specific role in bladder cancer (BC) remains undefined. This study aimed to elucidate the function of ADRM1 in BC throug...

Qing-xin Yu, Jiao-chen Wang, Jun-fei Liu, Lu-xia Ye, Yi-qing Guo… in Scientific Reports (2023)

Article

A randomized trial of Trendelenburg position for acute moderate ischemic stroke

We aim to explore the effect of head-down position (HDP), initiated within 24 hours of onset, in moderate anterior circulation stroke patients with probable large artery atherosclerosis (LAA) etiology. This in...

Hui-Sheng Chen, Nan-Nan Zhang, Yu Cui, **ao-Qiu Li, Cheng-Shu Zhou… in Nature Communications (2023)

Article

Use of dual genomic sequencing to screen mitochondrial diseases in pediatrics: a retrospective analysis

Mitochondrial diseases (MDs) were a large group multisystem disorders, attributable in part to the dual genomic control. The advent of massively sequencing has improved diagnostic rates and speed, and was incr...

Teng-Hui Wu, **g Peng, Li Yang, Yan-Hui Chen, **u-Lan Lu… in Scientific Reports (2023)

Article

An electric molecular motor

Macroscopic electric motors continue to have a large impact on almost every aspect of modern society. Consequently, the effort towards develo** molecular motors^1–3 that can be driven by electricity could not be...

Long Zhang, Yunyan Qiu, Wei-Guang Liu, Hongliang Chen, Dengke Shen, Bo Song… in Nature (2023)

Article

Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma

Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but are limited by insufficient and non-selective catalytic activities. Herein, ...

Shaofang Zhang, Yonghui Li, Si Sun, Ling Liu, **aoyu Mu, Shuhu Liu… in Nature Communications (2022)

Article

Author Correction: Comparative metabolomics study on therapeutic mechanism of electro-acupuncture and moxibustion on rats with chronic atrophic gastritis (CAG)

Cai-chun Liu, Jiao-long Chen, **ao-rong Chang, Qi-da He… in Scientific Reports (2022)

Article

TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models

Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts proliferate abnormally in th...

Jiao Wu, Zhuan Feng, Liang Chen, Yong Li, Huijie Bian, Jiejie Geng… in Nature Communications (2022)

Article

Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development

Metabolic programming and mitochondrial dynamics along with T cell differentiation affect T cell fate and memory development; however, how to control metabolic reprogramming and mitochondrial dynamics in T cel...

Jianli He, Xun Shangguan, Wei Zhou, Ying Cao, Quan Zheng, Jun Tu… in Nature Communications (2021)

Article

Evaluation of dose-volume histogram prediction for organ-at risk and planning target volume based on machine learning

The purpose of this work is to evaluate the performance of applying patient dosimetric information induced by individual uniform-intensity radiation fields in organ-at risk (OAR) dose-volume histogram (DVH) pr...

Sheng xiu Jiao, Ming li Wang, Li xin Chen, **ao-wei Liu in Scientific Reports (2021)

Article

Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, **ng-Lou Yang, **an-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang… in Nature (2020)

Article

Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

The mechanistic target of rapamycin complex 1 (mTORC1) integrates growth, nutrient and energy status cues to control cell growth and metabolism. While mTORC1 activation at the lysosome is well characterized, i...

**n Zhou, Yanghao Zhong, Olivia Molinar-Inglis, Maya T. Kunkel… in Nature Communications (2020)

Article

A spinal neural circuitry for converting touch to itch sensation

Touch and itch sensations are crucial for evoking defensive and emotional responses, and light tactile touch may induce unpleasant itch sensations (mechanical itch or alloknesis). The neural substrate for touc...

Sihan Chen, **ao-Fei Gao, Yuxi Zhou, Ben-Long Liu, **an-Yu Liu… in Nature Communications (2020)

Article

Machine learning based early warning system enables accurate mortality risk prediction for COVID-19

Soaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed health facilities have endeavored to mitigate the pandemic, but mortality of COVID-19 continues to increase. ...

Yue Gao, Guang-Yao Cai, Wei Fang, Hua-Yi Li, Si-Yuan Wang… in Nature Communications (2020)

Article

Publisher Correction: Orexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Hui Feng, Si-Yi Wen, Qi-Cheng Qiao, Yu-Jie Pang, Sheng-Yun Wang… in Nature Communications (2020)

Article

Orexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep

The relationship between orexin/hypocretin and rapid eye movement (REM) sleep remains elusive. Here, we find that a proportion of orexin neurons project to the sublaterodorsal tegmental nucleus (SLD) and exhib...

Hui Feng, Si-Yi Wen, Qi-Cheng Qiao, Yu-Jie Pang, Sheng-Yun Wang… in Nature Communications (2020)

Article

Substantia nigra echogenicity is associated with serum ferritin, gender and iron-related genes in Parkinson’s disease

Substantia nigra (SN) hyperechogenicity is present in most Parkinson’s disease (PD) cases but is occasionally absent in some. To date, age, gender, disease severity, and other factors have been reported to be ...

Kai Li, Yi-Lun Ge, Chen-Chen Gu, **-Ru Zhang, Hong **, Jiao Li… in Scientific Reports (2020)