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Open AccessID1 expressing macrophages support cancer cell stemness and limit CD8+ T cell infiltration in colorectal cancer
Elimination of cancer stem cells (CSCs) and reinvigoration of antitumor immunity remain unmet challenges for cancer therapy. Tumor-associated macrophages (TAMs) constitute the prominant population of immune ce...
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Open AccessA single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotype
Increasing evidence shows the African lineage Zika virus (ZIKV) displays a more severe neurovirulence compared to the Asian ZIKV. However, viral determinants and the underlying mechanisms of enhanced virulence...
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Open AccessRelationship between body composition and pulmonary function in the general population—a cross-sectional study in Ningxia
Studies considering the relationship between non-obesity-related body composition and lung function are few; therefore, this study aimed to explore these correlations and effects. This cross-sectional study co...
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Open AccessAdhesion-regulating molecule 1 (ADRM1) can be a potential biomarker and target for bladder cancer
Adhesion-regulating molecule 1 (ADRM1) has been implicated in tumor development, yet its specific role in bladder cancer (BC) remains undefined. This study aimed to elucidate the function of ADRM1 in BC throug...
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Open AccessA randomized trial of Trendelenburg position for acute moderate ischemic stroke
We aim to explore the effect of head-down position (HDP), initiated within 24 hours of onset, in moderate anterior circulation stroke patients with probable large artery atherosclerosis (LAA) etiology. This in...
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Open AccessUse of dual genomic sequencing to screen mitochondrial diseases in pediatrics: a retrospective analysis
Mitochondrial diseases (MDs) were a large group multisystem disorders, attributable in part to the dual genomic control. The advent of massively sequencing has improved diagnostic rates and speed, and was incr...
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Open AccessAn electric molecular motor
Macroscopic electric motors continue to have a large impact on almost every aspect of modern society. Consequently, the effort towards develo** molecular motors1–3 that can be driven by electricity could not be...
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Open AccessSingle-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma
Regenerable nanozymes with high catalytic stability and sustainability are promising substitutes for naturally-occurring enzymes but are limited by insufficient and non-selective catalytic activities. Herein, ...
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Electron-catalysed molecular recognition
Molecular recognition1–4 and supramolecular assembly5–8 cover a broad spectrum9–11 of non-covalently orchestrated phenomena between molecules. Catalysis12 of such processes, however, unlike that for the formation...
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Open AccessAuthor Correction: Comparative metabolomics study on therapeutic mechanism of electro-acupuncture and moxibustion on rats with chronic atrophic gastritis (CAG)
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Open AccessTNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models
Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts proliferate abnormally in th...
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Open AccessGlucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development
Metabolic programming and mitochondrial dynamics along with T cell differentiation affect T cell fate and memory development; however, how to control metabolic reprogramming and mitochondrial dynamics in T cel...
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Open AccessEvaluation of dose-volume histogram prediction for organ-at risk and planning target volume based on machine learning
The purpose of this work is to evaluate the performance of applying patient dosimetric information induced by individual uniform-intensity radiation fields in organ-at risk (OAR) dose-volume histogram (DVH) pr...
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Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin
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Open AccessLocation-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus
The mechanistic target of rapamycin complex 1 (mTORC1) integrates growth, nutrient and energy status cues to control cell growth and metabolism. While mTORC1 activation at the lysosome is well characterized, i...
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Open AccessA spinal neural circuitry for converting touch to itch sensation
Touch and itch sensations are crucial for evoking defensive and emotional responses, and light tactile touch may induce unpleasant itch sensations (mechanical itch or alloknesis). The neural substrate for touc...
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Open AccessMachine learning based early warning system enables accurate mortality risk prediction for COVID-19
Soaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed health facilities have endeavored to mitigate the pandemic, but mortality of COVID-19 continues to increase. ...
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Open AccessPublisher Correction: Orexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessOrexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep
The relationship between orexin/hypocretin and rapid eye movement (REM) sleep remains elusive. Here, we find that a proportion of orexin neurons project to the sublaterodorsal tegmental nucleus (SLD) and exhib...
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Open AccessSubstantia nigra echogenicity is associated with serum ferritin, gender and iron-related genes in Parkinson’s disease
Substantia nigra (SN) hyperechogenicity is present in most Parkinson’s disease (PD) cases but is occasionally absent in some. To date, age, gender, disease severity, and other factors have been reported to be ...