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Article
Unveiling novel genetic variants in 370 challenging medically relevant genes using the long read sequencing data of 41 samples from 19 global populations
Background: A large number of challenging medically relevant genes (CMRGs) are situated in complex or highly repetitive regions of the human genome, hindering comprehensive characterization of genetic variants...
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Article
Systemic analysis of the prognostic significance and interaction network of miR-26b-3p in cholangiocarcinoma
MicroRNAs (miRNAs) reportedly play significant roles in the progression of various cancers and hold huge potential as both diagnostic tools and therapeutic targets. Given the ongoing uncertainty surrounding th...
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Article
Open AccessThe causal relationship between blood cell indices and 28-day mortality in sepsis: a retrospective study and bidirectional Mendelian randomization analysis
Despite emerging evidence linking blood cell indices (BCIs) to sepsis mortality, the inconsistency of observational studies obscures the clarity of these associations. This study aims to clarify the causal inf...
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Article
Open AccessField cabbage detection and positioning system based on improved YOLOv8n
Pesticide efficacy directly affects crop yield and quality, making targeted spraying a more environmentally friendly and effective method of pesticide application. Common targeted cabbage spraying methods ofte...
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Article
Open AccessMachine learning constructs a diagnostic prediction model for calculous pyonephrosis
In order to provide decision-making support for the auxiliary diagnosis and individualized treatment of calculous pyonephrosis, the study aims to analyze the clinical features of the condition, investigate its...
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Article
Open AccessAltered immune pathways in patients of temporal lobe epilepsy with and without hippocampal sclerosis
Over the past decades, the immune responses have been suspected of participating in the mechanisms for epilepsy. To assess the immune related pathway in temporal lobe epilepsy (TLE), we explored the altered im...
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Article
Measurement and comparison of nutrients, bioactivity of four wild edible plants from Apiaceae family
In this experiment, four wild edible plants of Apiaceae species were studied, and their morphological indexes, ash, polysaccharide, protein, fat and mineral contents were determined. Significant variations were f...
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Article
The dual function of cGAS-STING signaling axis in liver diseases
Numerous liver diseases, such as nonalcoholic fatty liver disease, hepatitis, hepatocellular carcinoma, and hepatic ischemia-reperfusion injury, have been increasingly prevalent, posing significant threats to ...
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Article
Mechanism of Paris polyphylla saponin II inducing autophagic to inhibit angiogenesis of cervical cancer
Paris polyphylla saponin II (PPII) has good biological activity in inhibiting tumor angiogenesis. However, the mechanism of its action is still unclear. This study first observed the inhibitory effect of PPII on ...
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Article
Mesoporous K-doped MoVTeNbOx Catalyze the Direct Oxidation of Propane to Acrylic Acid
K-doped MoVTeNbOx were prepared rapidly and simply by spray drying method and applied to catalyze the selective oxidation of propane to acrylic acid. Results show that do** of K could affect the relative conten...
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Article
Experimental observation of the significant difference between surface and bulk Kondo processes in Kondo lattice YbCu2Si2
Synchrotron-based angle-resolved photoemission spectroscopy was employed to investigate the temperature evolution of the Yb 4f spectral for surface and bulk in the Kondo lattice YbCu2Si2. Our study quantitatively...
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Article
Curcumol Attenuates Portal Hypertension and Collateral Shunting Via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats
Liver cirrhosis can cause disturbances in blood circulation in the liver, resulting in impaired portal blood flow and ultimately increasing portal venous pressure. Portal hypertension induces portal-systemic c...
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Article
Open AccessThe use of Enhanced Vegetation Index for assessing access to different types of green space in epidemiological studies
Exposure to green space can protect against poor health through a variety of mechanisms. However, there is heterogeneity in methodological approaches to exposure assessments which makes creating effective poli...
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Article
Cr-doped Mesoporous M1 Phase MoVTeNbOx Catalyze Selective Oxidation of Propane to Acrylic Acid
In this work, MoVTeNbOx catalysts was doped with Cr by using spray drying method. The effect of Cr do** on the crystalline phase, physicochemical properties, and catalytic performance of selective oxidation of ...
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Article
Petrogenesis and tectonic implications of the Silurian adakitic granitoids in the eastern segment of the Qilian Orogenic Belt, Northwest China
Geodynamic mechanism responsible for the generation of Silurian granitoids and the tectonic evolution of the Qilian orogenic belt remains controversial. In this study, we report the results of zircon U–Pb age,...
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Article
Open AccessA wearable electrostimulation-augmented ionic-gel photothermal patch doped with MXene for skin tumor treatment
A wearable biological patch capable of producing multiple responses to light and electricity without interfering with daily activities is highly desired for skin cancer treatment, but remains a key challenge. ...
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Article
Open AccessFactors predicting depressive symptoms in parents of children with autism spectrum disorder in eastern China
Parents of children with autism spectrum disorder (ASD) are at a higher risk of depression than parents of typically develo** children and those of children with other developmental disorders. Depression aff...
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Article
Open AccessMaternal uniparental disomy for chromosome 6 in 2 prenatal cases with IUGR: case report and literature review
Uniparental disomy (UPD) is a rare genetic condition leading to potential disease risks. Maternal UPD of chromosome 6 upd(6)mat is exceptionally rare, with limited cases reported. This study reported two new c...
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Article
The shear strength of the interface between artificial rock and printed concrete at super-early ages
3D concrete printing has the potential to replace shotcrete for construction of linings of tunnels in hard rock. The shear strength of the interface between rock and printed concrete is vital, especially at su...
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Article
LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles
Liver fibrosis is a wound-healing process characterized by excess formation of extracellular matrix (ECM) from activated hepatic stellate cells (HSCs). Previous studies show that both EZH2, an epigenetic regul...
