1,098 Result(s)
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Article
Open AccessTracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases
Many CRISPR-Cas immune systems generate guide (g)RNAs using trans-activating CRISPR RNAs (tracrRNAs). Recent work revealed that Cas9 tracrRNAs could be reprogrammed to convert any RNA-of-interest into a gRNA, ...
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Open AccessNumerical simulation on transient electromagnetic response of separation layer water in coal seam roof
Mining stress induces deformation and fracture of the overlaying rock, which will result in water filling the separation layer if the aquifer finds access to abscission space along the fracture channels. Accur...
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Open AccessMechanisms underlying the therapeutic effects of Gang Huo Qing wen granules in the treatment of influenza based on network pharmacology, molecular docking and molecular dynamics
Influenza (Flu) is a severe health, medical, and economic problem, but no medication that has excellent outcomes and lowers the occurrence of these problems is now available. GanghuoQingwenGranules (GHQWG) is a c...
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Open AccessStructured connectivity in the output of the cerebellar cortex
The spatial organization of a neuronal circuit is critically important for its function since the location of neurons is often associated with function. In the cerebellum, the major output of the cerebellar co...
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Open AccessA retrospective observational study evaluating the association between vasoactive–inotropic score and mortality after major abdominal surgery
The relationship between VISmax and mortality in patients undergoing major abdominal surgery remains unclear. This study aims to evaluate the association between VISmax and both short-term and long-term all-cause...
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Open AccessExploring the feasibility of Zr-based metal–organic frameworks for the recovery of Sb (V) and Sb (III) from mining waste
The present study investigates the efficacy of newly developed Zr-based metal–organic frameworks, specifically MIP-206, and its amine-modified counterpart, MIP-206-NH2, for the re-covery of antimony (Sb) from bot...
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Open AccessAudio-visual modelling in a clinical setting
Auditory and visual signals are two primary perception modalities that are usually present together and correlate with each other, not only in natural environments but also in clinical settings. However, audio...
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Open AccessThe effects of temperament type on infusion extravasation in newborns
Infusion extravasation has an increased incidence in newborns, which can result in various adverse outcomes. This study aimed to investigate the effects of different types of temperament on infusion extravasat...
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Open AccessAnalysis of the multiple drivers of vegetation cover evolution in the Taihangshan-Yanshan region
The Taihangshan-Yanshan region (TYR) is an important ecological barrier area for Bei**g-Tian**-Hebei, and the effectiveness of its ecological restoration and protection is of great significance to the ecolog...
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Open AccessTemperature-dependent jumonji demethylase modulates flowering time by targeting H3K36me2/3 in Brassica rapa
Global warming has a severe impact on the flowering time and yield of crops. Histone modifications have been well-documented for their roles in enabling plant plasticity in ambient temperature. However, the fa...
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Open AccessGlobal turnover of soil mineral-associated and particulate organic carbon
Soil organic carbon (SOC) persistence is predominantly governed by mineral protection, consequently, soil mineral-associated (MAOC) and particulate organic carbon (POC) turnovers have different impacts on the ...
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Open AccessGenome-wide identification of starch phosphorylase gene family in Rosa chinensis and expression in response to abiotic stress
Chinese rose (Rosa chinensis) is an important ornamental plant, with economic, cultural, and symbolic significance. During the application of outdoor greening, adverse environments such as high temperature and dr...
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Open AccessTranscriptomic annotation of the Chungtien schizothoracin (Ptychobarbus chungtienensis) using Iso-seq and RNA-seq data
The Chungtien schizothoracin (Ptychobarbus chungtienensis), an endangered fish species endemic to the Zhongdian Plateau, remains underexplored in terms of transcriptomic sequencing. This investigation used tissue...
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Open AccessAltered immune pathways in patients of temporal lobe epilepsy with and without hippocampal sclerosis
Over the past decades, the immune responses have been suspected of participating in the mechanisms for epilepsy. To assess the immune related pathway in temporal lobe epilepsy (TLE), we explored the altered im...
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Open AccessMetallaphotoredox deuteroalkylation utilizing thianthrenium salts
Deuterium labeling compounds play a crucial role in organic and pharmaceutical chemistry. The synthesis of such compounds typically involves deuterated building blocks, allowing for the incorporation of deuter...
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Open AccessSampling unknown large networks restricted by low sampling rates
Graph sampling plays an important role in data mining for large networks. Specifically, larger networks often correspond to lower sampling rates. Under the situation, traditional traversal-based samplings for ...
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Open AccessElectrical switching of Ising-superconducting nonreciprocity for quantum neuronal transistor
Nonreciprocal quantum transport effect is mainly governed by the symmetry breaking of the material systems and is gaining extensive attention in condensed matter physics. Realizing electrical switching of the ...
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Open AccessLDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy
Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the...
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Open AccessFully exposed Pt clusters for efficient catalysis of multi-step hydrogenation reactions
For di-nitroaromatics hydrogenation, it is a challenge to achieve the multi-step hydrogenation with high activity and selectivity due to the complexity of the process involving two nitro groups. Consequently, ...
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Open AccessHaplotype-resolved chromosome-level genome assembly of Ehretia macrophylla
Ehretia macrophylla Wall, known as wild loquat, is an ecologically, economically, and medicinally significant tree species widely grown in China, Japan, Vietnam, and Nepal. In this study, we have successfully gen...
