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Article
Open AccessValidation of a novel model for the early detection of hepatocellular carcinoma
The biomarkers alpha-fetoprotein (AFP) and protein induced by vitamin K absence/antagonist-II (PIVKA-II) may be useful for detecting early-stage hepatocellular carcinoma (HCC). We evaluated the performance of ...
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Article
Open AccessGenetic editing of HLA expression in hematopoietic stem cells to broaden their human application
Mismatch of human leukocyte antigens (HLA) adversely impacts the outcome of patients after allogeneic hematopoietic stem-cell transplantation (alloHSCT). This translates into the clinical requirement to timely...
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Article
Open AccessThe genome of Mesobuthus martensii reveals a unique adaptation model of arthropods
Representing a basal branch of arachnids, scorpions are known as ‘living fossils’ that maintain an ancient anatomy and are adapted to have survived extreme climate changes. Here we report the genome sequence of M...
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Article
Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity
Leukocyte telomere length is widely considered a biomarker of human age and in many studies indicative of health or disease. We have obtained quantitative estimates of telomere length from blood leukocytes in ...
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Article
Development of transgenic hybrid sweetgum (Liquidambar styraciflua × L. formosana) expressing γ-glutamylcysteine synthetase or mercuric reductase for phytoremediation of mercury pollution
Using Agrobacterium-mediated gene transfer, we generated transgenic hybrid sweetgum (Liquidambar styraciflua × L. formosana) overexpressing two types of genes to enhance plant remediation of mercury-contaminated ...
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Article
Cloning and characterization of a novel human phosphatidic acid phosphatase type 2, PAP2d, with two different transcripts PAP2d_v1 and PAP2d_v2
This study reports the cloning and characterization of a novel human phosphatidic acid phosphatase type 2 isoform cDNAs (PAP2d) from the foetal brain cDNA library. The PAP2d gene is localized on chromosome 1p21.3...
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Article
Enhancing the productivity of hybrid yellow-poplar and hybrid sweetgum embryogenic cultures
High-frequency embryogenesis systems were established for hybrid yellow-poplar (Liriodendron tulipifera×L. chinense) and hybrid sweetgum (Liquidambar styraciflua×L. formosana) by modifying a medium originally dev...
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Article
Cloning and characterization of the human IFT20 gene*
Intraflagellar transport (IFT), in which molecular motors and IFT particle proteins participate, is very important in assembling and maintaining many cilia/flagella, such as the motile cilia that drive the swi...
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Article
Characterization of a novel splicing variant of KLHL5 *, a member of the kelch protein family
The kelch-repeat protein family is a recently found new kind of actin-binding protein. It is characterized by tandemly arranged motifs of about 50 amino acids [7]. Previous study showed that most members of th...
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Article
Isolation and identification of a novel cDNA that encodes human yrdC protein
In the course of detecting the interaction protein of RBBP10 by yeast two-hybridization, we isolated a novel cDNA that encodes a putative human protein with yrdC domain. It is named human yrdC protein. Because...
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Article
Cloning and expression of a novel human C5orf12 gene, a member of the TMS_TDE family
We report here cloning and characterization of a novel human gene, termed C5orf12, which is a putative membrane protein belonging to the TMS_TDE family. The cDNA encodes 42 animo acid with a putative molecular...
