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Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity

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  1. Article

    Open Access

    Validation of a novel model for the early detection of hepatocellular carcinoma

    The biomarkers alpha-fetoprotein (AFP) and protein induced by vitamin K absence/antagonist-II (PIVKA-II) may be useful for detecting early-stage hepatocellular carcinoma (HCC). We evaluated the performance of ...

    Philip M. Hemken, Lori J. Sokoll, **aoqing Yang, Jianliang Dai in Clinical Proteomics (2019)

  2. Article

    Open Access

    Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application

    Mismatch of human leukocyte antigens (HLA) adversely impacts the outcome of patients after allogeneic hematopoietic stem-cell transplantation (alloHSCT). This translates into the clinical requirement to timely...

    Hiroki Torikai, Tiejuan Mi, Loren Gragert, Martin Maiers, Amer Najjar in Scientific Reports (2016)

  3. Article

    Open Access

    The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods

    Representing a basal branch of arachnids, scorpions are known as ‘living fossils’ that maintain an ancient anatomy and are adapted to have survived extreme climate changes. Here we report the genome sequence of M...

    Zhijian Cao, Yao Yu, Yingliang Wu, Pei Hao, Zhiyong Di, Yawen He in Nature Communications (2013)

  4. Article

    Isolation and identification of a novel cDNA that encodes human yrdC protein

    In the course of detecting the interaction protein of RBBP10 by yeast two-hybridization, we isolated a novel cDNA that encodes a putative human protein with yrdC domain. It is named human yrdC protein. Because...

    **zhong Chen, Chaoneng Ji, Shaohua Gu, Enpeng Zhao in Journal of Human Genetics (2003)