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Article
Open AccessRole of PRKDC in cancer initiation, progression, and treatment
The PRKDC gene encodes the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein. DNA-PKcs plays an important role in nonhomologous end joining (NHEJ) of DNA double-strand breaks (DSBs) and is also cl...
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Article
CPSF4 regulates circRNA formation and microRNA mediated gene silencing in hepatocellular carcinoma
CircRNAs play essential roles in various physiological processes and involves in many diseases, in particular cancer. Global downregulation of circRNA expression has been observed in hepatocellular carcinoma (...