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Article
Open AccessGenetic assessment and candidate genes identification for breed-specific characteristics of Qingyuan partridge chicken based on runs of homozygosity
Several core breeding and supporting lines of the Qingyuan partridge chicken, a representative local chicken breed in China, have been developed over 20 years. Consequently, its economic traits related to grow...
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Article
Imaging surface structure and premelting of ice Ih with atomic resolution
Ice surfaces are closely relevant to many physical and chemical properties, such as melting, freezing, friction, gas uptake and atmospheric reaction1–8. Despite extensive experimental and theoretical investigatio...
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Article
Nanoscale one-dimensional close packing of interfacial alkali ions driven by water-mediated attraction
The permeability and selectivity of biological and artificial ion channels correlate with the specific hydration structure of single ions. However, fundamental understanding of the effect of ion–ion interactio...
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Article
Optimization of real-time dynamic cargo stowage at highway freight stations
The stowage process of highway freight vehicles is a key link in Intelligent Logistics Transportation System. This paper is based on vehicle prediction to achieve the arrival time and the quantity of cargo-lad...
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Article
Associations of CKIP-1 and LOX-1 polymorphisms with the risk of type 2 diabetes mellitus with hypertension among Chinese adults
Type 2 diabetes mellitus (T2DM) and hypertension are common high-incidence diseases, closely related, and have common pathogenic basis such as oxidative stress. Casein kinase 2 interacting protein-1 (CKIP-1) and ...
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Article
Open AccessSETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy
SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch repair (MMR) in neoplastic cells. However, it remains unclear whether SETD2 dysfunction is a comple...
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Article
Open AccessClonal evolution analyses of a chronic myeloid leukemia patient with hematopoietic stem cell transplantation based on deep sequencing
The Philadelphia (Ph) chromosome is the hallmark chromosome aberration in chronic myeloid leukemia (CML), which confers the cancer phenotype of the disease. However, how the Ph chromosome forms and the genetic...
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Article
Spatially explicit changes of forestland in Taiwan Province from 1910 to 2010
Reconstructing long-term changes of forest cover (FC) can provide reliable underlying data for carbon source/sink accounting and simulation of the effects of land use on the climate and environment. Historical...
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Article
Open AccessRole of PRKDC in cancer initiation, progression, and treatment
The PRKDC gene encodes the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein. DNA-PKcs plays an important role in nonhomologous end joining (NHEJ) of DNA double-strand breaks (DSBs) and is also cl...
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Article
Preparation of a novel EGFR specific immunotoxin and its efficacy of anti-colorectal cancer in vitro and in vivo
Epithelial growth factor receptor (EGFR), as a malignancy marker, is overly expressed in multiple solid tumors including colorectal neoplasms, one of the most prevalent malignancies worldwide. The main objecti...
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Article
CPSF4 regulates circRNA formation and microRNA mediated gene silencing in hepatocellular carcinoma
CircRNAs play essential roles in various physiological processes and involves in many diseases, in particular cancer. Global downregulation of circRNA expression has been observed in hepatocellular carcinoma (...
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Chapter and Conference Paper
Internet of Things Information Construction Combined with Big Data in Cloud Computing Environment
With the advent of the cloud computing era, many convenient conditions have been proposed for people to work and live. This shows the importance of cloud technology development and application. On the basis of...
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Article
Open AccessTriglyceride is an independent predictor of type 2 diabetes among middle-aged and older adults: a prospective study with 8-year follow-ups in two cohorts
Although there is abundant evidence indicating the connection between triglyceride and type 2 diabetes mellitus (T2DM), few reports or cohort studies confirm that high TG concentration may predict the incidenc...
