319 Result(s)

Article

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neur...

**xi Guo, **aosa Zhao, ** Lu, Li** Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Lathyrol reduces the RCC invasion and incidence of EMT via affecting the expression of AR and SPHK2 in RCC mice

To investigate the effects of Lathyrol on the expression of androgen receptor (AR) and sphingosine kinase 2 (SPHK2) in renal cell carcinoma (RCC) mice and to further explore the mechanism by which Lathyrol inh...

Shengyou Song, Lunwei Tai, Yuqi Xu, Junling Jiang, Lei Zhou… in Discover Oncology (2024)

Article

Mechanistic insights into ¹²⁵I seed implantation therapy for Cholangiocarcinoma: focus on ROS-Mediated apoptosis and the role of GPX2

Cholangiocarcinoma (CCA) is a rare tumor with a poor prognosis and poses significant therapeutic challenges. Herein, we investigated the mechanism of efficacy of ¹²⁵I seed implantation therapy in CCA, focusing on...

Jun Luo, Zheng Yao, Weiren Liang… in Journal of Cancer Research and Clinical On… (2024)

Article

Zero-profile implant system versus novel plate systems after ACDF for comparison of sagittal balance parameters and clinical efficacy analysis

The zero-profile implant system (Zero-P) and conventional plates have been widely used in anterior cervical discectomy and fusion (ACDF) to treat cervical spondylosis. The purpose of this study was to compare ...

Yan Gong, Hang Zhuo, Zelin Zhou… in Journal of Orthopaedic Surgery and Research (2024)

Article

Risk factors for subsequent fractures in hip fracture patients: a nested case-control study

The risk factors for subsequent fractures following an initial hip fracture are not entirely understood. This study examined the clinical characteristics of hip fracture patients to identify potential risk fac...

Mi Song, Yilin Wang, Yu Jiang, Hongying Pi… in Journal of Orthopaedic Surgery and Research (2024)

Article

Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives

Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) a...

**an-Bin Zhang, Yi-Bao Fan, Rui **g, Mikiyas Amare Getu… in Military Medical Research (2024)

Article

Correction to: Safety and immunogenicity of SARS-CoV-2 vaccines in Chinese patients with cirrhosis: a prospective multicenter study

Jitao Wang, Qiran Zhang, **gwen Ai, Dengxiang Liu, Chuan Liu… in Hepatology International (2024)

Article

A multicenter prospective study on the management of hepatoblastoma in children: a report from the Chinese Children’s Cancer Group

This study aimed to identify survival risk factors in Chinese children with hepatoblastoma (HB) and assess the effectiveness of the new treatment protocol proposed by the Chinese Children’s Cancer Group (CCCG)...

Meng-Jie Tang, **ao-Li Ma, **ang-Ling He, Wei-Hua Pan… in World Journal of Pediatrics (2024)

Article

A rare case report: multiple intrahepatic masses in a pediatric patient with citrin deficiency

Deficiency of citrin, the liver-type aspartate-glutamate carrier, arises from biallelic mutations of the gene SLC25A13. Although citrin deficiency (CD) is associated with higher risk of hepatocellular carcinom...

Hui Lin, Hong Jiang, Qiang Chen, **ang Pan, Mei Deng, **ang-Ran Cai… in Discover Oncology (2024)

Article

A deep learning-based radiomics model for predicting lymph node status from lung adenocarcinoma

At present, there are many limitations in the evaluation of lymph node metastasis of lung adenocarcinoma. Currently, there is a demand for a safe and accurate method to predict lymph node metastasis of lung ca...

Hui **e, Chaoling Song, Lei Jian, Yeang Guo, Mei Li, Jiang Luo… in BMC Medical Imaging (2024)

Article

Long-term outcome and fertility results of intraplacental choriocarcinoma: a retrospective study of 14 patients and literature review

Intraplacental choriocarcinoma (IC) is an extremely rare subtype of gestational choriocarcinoma. The long-term follow-up and reproductive outcomes of IC patients remain unclear. Here, we report a series of 14 ...

Yang Liu, **aochen Song, Hui Zhang, Fengzhi Feng… in Orphanet Journal of Rare Diseases (2024)

Article

MRI radiomics based on deep learning automated segmentation to predict early recurrence of hepatocellular carcinoma

To investigate the utility of deep learning (DL) automated segmentation-based MRI radiomic features and clinical-radiological characteristics in predicting early recurrence after curative resection of single h...

Hong Wei, Tianying Zheng, **aolan Zhang, Yuanan Wu, Yidi Chen… in Insights into Imaging (2024)

Article

Development and validation of a nomogram to predict postoperative delirium in older patients after major abdominal surgery: a retrospective case-control study

Postoperative delirium is a common complication in older patients, with poor long-term outcomes. This study aimed to investigate risk factors and develop a predictive model for postoperative delirium in older ...

Yun-Gen Luo, **ao-Dong Wu, Yu-**ang Song, **ao-Lin Wang, Kai Liu… in Perioperative Medicine (2024)

Article

Unraveling transcriptomic signatures and dysregulated pathways in systemic lupus erythematosus across disease states

This study aims to elucidate the transcriptomic signatures and dysregulated pathways in patients with Systemic Lupus Erythematosus (SLE), with a particular focus on those persisting during disease remission.

Frank Qingyun Wang, Li Shao, **ao Dang, Yong-Fei Wang… in Arthritis Research & Therapy (2024)

Article

Pharmaceutical treatment status of patients with COPD in the community based on medical Internet of Things: a real-world study

This study aimed to investigate the real-world standardisation and adherence of medical treatment regimens in patients with chronic obstructive pulmonary disease (COPD) in the community for making future manag...

Peng Wu, Yi-qun Jiang, Feng-li Si, Huan-ying Wang… in npj Primary Care Respiratory Medicine (2024)

Article

Analysis of hemorrhage upon ultrasound-guided percutaneous renal biopsy in China: a retrospective study

Ultrasound-guided percutaneous renal biopsy (PRB) has been considered as a golden standard for CKD diagnosis and is employed to identify potential therapeutic targets since 1950s. Post-biopsy hemorrhage is the...

Fang-fang Li, Yu-xia Guan, Tong-xin Li, Di Jiang… in International Urology and Nephrology (2024)

Article

Prognostic MRI features to predict postresection survivals for very early to intermediate stage hepatocellular carcinoma

Contrast-enhanced MRI can provide individualized prognostic information for hepatocellular carcinoma (HCC). We aimed to investigate the value of MRI features to predict early (≤ 2 years)/late (> 2 years) recur...

Hanyu Jiang, Yun Qin, Hong Wei, Tianying Zheng, Ting Yang, Yuanan Wu… in European Radiology (2024)

Article

Effects of the stress hyperglycemia ratio on long-term mortality in patients with triple-vessel disease and acute coronary syndrome

Risk assessment for triple-vessel disease (TVD) remain challenging. Stress hyperglycemia represents the regulation of glucose metabolism in response to stress, and stress hyperglycemia ratio (SHR) is recently ...

Yu Zhang, Lei Guo, Hao Zhu, Lin Jiang, Lianjun Xu, Dong Wang… in Cardiovascular Diabetology (2024)

Article

Early progression is associated with worse survival in patients with Waldenström’s macroglobulinemia

Early progression of disease within 24 months (POD24) of diagnosis is associated with inferior overall survival (OS) in follicular lymphoma, but its prognostic role in Waldenström’s macroglobulinemia (WM) is s...

Wenjie **ong, Zanzan Wang, Huihan Wang, Chunrui Li… in Holistic Integrative Oncology (2024)

Article

Efficacy and adverse reactions of peripheral add multifocal soft contact lenses in childhood myopia: a meta-analysis

This study aims to compare the efficacy of peripheral add multifocal soft contact lenses (SCLs) (excluding bifocal SCLs) with single vision contact lenses or spectacles in controlling myopia progression.

Desheng Song, Wen Qiu, Ting Jiang, Zhijun Chen, Juan Chen in BMC Ophthalmology (2024)