72 Result(s)

Article

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neur...

**xi Guo, **aosa Zhao, ** Lu, Li** Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Lathyrol reduces the RCC invasion and incidence of EMT via affecting the expression of AR and SPHK2 in RCC mice

To investigate the effects of Lathyrol on the expression of androgen receptor (AR) and sphingosine kinase 2 (SPHK2) in renal cell carcinoma (RCC) mice and to further explore the mechanism by which Lathyrol inh...

Shengyou Song, Lunwei Tai, Yuqi Xu, Junling Jiang, Lei Zhou… in Discover Oncology (2024)

Article

Mechanistic insights into ¹²⁵I seed implantation therapy for Cholangiocarcinoma: focus on ROS-Mediated apoptosis and the role of GPX2

Cholangiocarcinoma (CCA) is a rare tumor with a poor prognosis and poses significant therapeutic challenges. Herein, we investigated the mechanism of efficacy of ¹²⁵I seed implantation therapy in CCA, focusing on...

Jun Luo, Zheng Yao, Weiren Liang… in Journal of Cancer Research and Clinical On… (2024)

Article

A rare case report: multiple intrahepatic masses in a pediatric patient with citrin deficiency

Deficiency of citrin, the liver-type aspartate-glutamate carrier, arises from biallelic mutations of the gene SLC25A13. Although citrin deficiency (CD) is associated with higher risk of hepatocellular carcinom...

Hui Lin, Hong Jiang, Qiang Chen, **ang Pan, Mei Deng, **ang-Ran Cai… in Discover Oncology (2024)

Article

Identification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6

Abnormal expression of protein tyrosine kinase 6 (PTK6) has been proven to be involved in the development of gynecological tumors. However, its immune-related carcinogenic mechanism in other tumors remains unc...

Ren-Hui **ong, Shuo-Qi Yang, Ji-Wei Li, Xun-kai Shen, Lu-Ming **… in Discover Oncology (2024)

Article

Targeting CD24/Siglec-10 signal pathway for cancer immunotherapy: recent advances and future directions

The small, heavily glycosylated protein CD24 is primarily expressed by many immune cells and is highly expressed mostly in cancer cells. As one of the most crucial biomarkers of cancers, CD24 is frequently hig...

**ngchen Li, Wenzhi Tian, Zhongxing Jiang… in Cancer Immunology, Immunotherapy (2024)

Article

Surgical treatment strategy for thymic tumors invading the superior vena cava

To explore surgical treatment strategies for thymic tumors invading the superior vena cava (SVC).

Jiahao Jiang, Jian Gao, Shuai Wang, Yongqiang Ao, Jieqiong Song… in Clinical Cancer Bulletin (2024)

Article

Targeting complement hyperactivation: a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection

Leili Jia, Haihua Luo, Lizhong Li, Mingyao Wang… in Signal Transduction and Targeted Therapy (2023)

Article

Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and nivolumab–chemotherapy (N/C) combinations based on PD-L1 expression. Eligible patients exh...

Si-Yang Liu, Song Dong, Xue-Ning Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the dis...

Lin Wang, Jia-Bao Cao, Bin-Bin **a, Yue-Juan Li… in Signal Transduction and Targeted Therapy (2023)

Article

Real-world evidence of osimertinib in Chinese patients with EGFR T790M-positive non-small cell lung cancer: a subgroup analysis from ASTRIS study

ASTRIS study aimed the largest to evaluate the effectiveness and safety of second- or higher-line osimertinib in patients with advanced/metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive n...

Qing Zhou, He-Long Zhang, Li-Yan Jiang… in Journal of Cancer Research and Clinical On… (2023)

Article

Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing

BCMA CAR-T is highly effective for relapsed/refractory multiple myeloma(R/R-MM) and significantly improves the survival of patients. However, the short remission time and high relapse rate of MM patients treat...

Wei Li, Binglei Zhang, Weijie Cao, Wenli Zhang… in Experimental Hematology & Oncology (2023)

Article

Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2

Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2. Here we report that nelfinavir, an FDA approved drug for the treatment of HIV infec...

Zhijian Xu, Danrong Shi, Jian-Bao Han, Yun Ling… in Signal Transduction and Targeted Therapy (2023)

Article

B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis

Hyperhomocysteinemia (HHcy) is a risk factor for chronic kidney diseases (CKDs) that affects about 85% CKD patients. HHcy stimulates B cells to secrete pathological antibodies, although it is unknown whether t...

**ng Du, **aolong Ma, Ying Tan, Fangyu Shao… in Signal Transduction and Targeted Therapy (2023)

Article

Correction: Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial

Qian Jiang, Zongru Li, Yazhen Qin, Weiming Li, Na Xu… in Journal of Hematology & Oncology (2023)

Article

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity

Interleukin-2 (IL-2) is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells (Tregs) and effector cells, leading to paradoxical consequences. Here, we report a strateg...

Bo Zhang, Jiaqi Sun, Yeshuang Yuan, Dezhong Ji… in Signal Transduction and Targeted Therapy (2023)

Article

Application of metabolomics in urolithiasis: the discovery and usage of succinate

Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic stone events. It has been shown that the occurrence of calcium oxalate monohydrate (COM) during stone formation is regu...

**u-zhen Zhang, **ong-xin Lei, Yan-lin Jiang… in Signal Transduction and Targeted Therapy (2023)