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Open AccessHarnessing three-dimensional porous chitosan microsphere embedded with adipose-derived stem cells to promote nerve regeneration
Nerve guide conduits are a promising strategy for reconstructing peripheral nerve defects. Improving the survival rate of seed cells in nerve conduits is still a challenge and microcarriers are an excellent th...
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Article
Open AccessImmunomodulatory effects of mesenchymal stem cells in peripheral nerve injury
Various immune cells and cytokines are present in the aftermath of peripheral nerve injuries (PNI), and coordination of the local inflammatory response is of great significance for the recovery of PNI. Mesench...
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Article
Open AccessFunctional tissue-engineered microtissue formed by self-aggregation of cells for peripheral nerve regeneration
Peripheral nerve injury (PNI) is one of the essential causes of physical disability with a high incidence rate. The traditional tissue engineering strategy, Top-Down strategy, has some limitations. A new tissu...
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Article
Open AccessUltrasound-guided platelet-rich plasma injection and multimodality ultrasound examination of peripheral nerve crush injury
Ultrasound-guided platelet-rich plasma (PRP) injection is able to make up for the limitations of applying a single growth factor. The goal of this study was to investigate the effects of serial ultrasound-guid...
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Article
Open AccessCo-culture of hWJMSCs and pACs in double biomimetic ACECM oriented scaffold enhances mechanical properties and accelerates articular cartilage regeneration in a caprine model
The dedifferentiation of chondrocytes and the unstable chondrogenic differentiation status of pluripotent mesenchymal stem cells (MSCs) are immense issues in cell-based articular cartilage repair and regenerat...
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Open AccessThe optimal time to inject bone mesenchymal stem cells for fracture healing in a murine model
Bone marrow is an important source of stem cells, which can promote bone fracture healing.
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Open AccessStem cell therapy for treating osteonecrosis of the femoral head: From clinical applications to related basic research
Osteonecrosis of the femoral head (ONFH) is a refractory disease that is associated with collapse of the femoral head, with a risk of hip arthroplasty in younger populations. Thus, there has been an increased ...
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Article
Open AccessDifferentiation of adipose-derived stem cells into Schwann cell-like cells through intermittent induction: potential advantage of cellular transient memory function
Peripheral nerve injury (PNI) is a worldwide issue associated with severe social and economic burden. Autologous nerve grafting, the gold standard treatment for peripheral nerve defects, still has a number of ...
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Article
Open AccessOsteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity
MicroRNAs have an important role in bone homeostasis. However, the detailed mechanism of microRNA-mediated intercellular communication between bone cells remains elusive. Here, we report that osteoclasts secre...