-
Article
Open AccessNew prediction method of horizontal principal stress of deep tight reservoirs
As the tight reservoir of Lucaogou Formation in Jimsar sag is characterized as large burial depth and poor physical properties, hydraulic fracturing technology is greatly needed to increase the production. Fir...
-
Article
Open AccessSimultaneous quantification of serum monounsaturated and polyunsaturated phosphatidylcholines as potential biomarkers for diagnosing non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is one of the most common malignancies worldwide. In this study, we investigated Ultrahigh Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry and G...
-
Article
Open AccessGenome-wide analyses of SWEET family proteins reveal involvement in fruit development and abiotic/biotic stress responses in banana
Sugars Will Eventually be Exported Transporters (SWEET) are a novel type of sugar transporter that plays crucial roles in multiple biological processes. From banana, for the first time, 25 SWEET genes which could...
-
Article
Open AccessGenome-wide analysis of banana MADS-box family closely related to fruit development and ripening
Proteins encoded by MADS-box genes are important transcription factors involved in the regulation of flowering plant growth and development. Currently, no systematic information exists regarding the MADS-box f...
-
Article
Open AccessIn situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line
To date, the exact targets and mechanism of action of curcumin, a natural product with anti-inflammatory and anti-cancer properties, remain elusive. Here we synthesized a cell permeable curcumin probe (Cur-P) wit...
-
Article
Open AccessHaem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
The mechanism of action of artemisinin and its derivatives, the most potent of the anti-malarial drugs, is not completely understood. Here we present an unbiased chemical proteomics analysis to directly explor...
-
Article
Open AccessMap** sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP)
Target-identification and understanding of mechanism-of-action (MOA) are challenging for development of small-molecule probes and their application in biology and drug discovery. For example, although aspirin ...