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Gasdermin D pore structure reveals preferential release of mature interleukin-1

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  1. Article

    Open Access

    NLRP inflammasomes in health and disease

    NLRP inflammasomes are a group of cytosolic multiprotein oligomer pattern recognition receptors (PRRs) involved in the recognition of pathogen-associated molecular patterns (PAMPs) and danger-associated molecu...

    Zhihao Xu, Arnaud John Kombe Kombe, Shasha Deng, Hongliang Zhang in Molecular Biomedicine (2024)

  2. Article

    Regulating GSDMB pore formation: to ignite or inhibit?

    In the recent Nature, Wang et al. and Zhong et al. present the cryo-EM structures of Gasdermin B (GSDMB) pore and strucures of GSDMB in complex with a Shigella effector, IpaH7.8. The structures shed light on the ...

    Jianbin Ruan in Cell Death & Differentiation (2023)

  3. Article

    Open Access

    Structural basis for GSDMB pore formation and its targeting by IpaH7.8

    Gasdermins (GSDMs) are pore-forming proteins that play critical roles in host defence through pyroptosis1,2. Among GSDMs, GSDMB is unique owing to its distinct lipid-binding profile and a lack of consensus on its...

    Chengliang Wang, Sonia Shivcharan, Tian Tian, Skylar Wright, Danyang Ma in Nature (2023)

  4. Article

    Open Access

    3D Artificial Array Interface Engineering Enabling Dendrite-Free Stable Zn Metal Anode

  5. The design concept of 3D artificial array interface engineering was proposed to achieve eliminated volume stress, preferred orientation growth and dendrite-free Zn metal anode.

  6. Jianbin Ruan, Dingtao Ma, Kefeng Ouyang, Sicheng Shen, Ming Yang in Nano-Micro Letters (2023)

  7. Article

    Open Access

    Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes

    NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular signalling complexes known as canonical inflammasomes, resulting in caspase−1 activation, cytokine maturation and/or pyrop...

    L. Robert Hollingsworth, Liron David, Yang Li, Andrew R. Griswold in Nature Communications (2021)

  8. Article

    Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation

    In the version of this article initially published, the label (CASP4-C285A-HA) above the second and fifth lanes in the right blot in Fig. 1e is incorrect; the correct label is CASP4-C258A-HA. Also, the two labels...

    Youn Jung Choi, Stephanie Kim, Younho Choi, Travis B. Nielsen, Jun Yan in Nature Immunology (2019)

  9. Article

    Open Access

    Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2

    Absent in melanoma 2 (AIM2) is an essential cytosolic double-stranded DNA receptor that assembles with the adaptor, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspa...

    Alvin Lu, Yang Li, Qian Yin, Jianbin Ruan, **ong Yu, Edward Egelman in Cell Discovery (2015)