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Article
Open AccessNLRP inflammasomes in health and disease
NLRP inflammasomes are a group of cytosolic multiprotein oligomer pattern recognition receptors (PRRs) involved in the recognition of pathogen-associated molecular patterns (PAMPs) and danger-associated molecu...
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Article
Regulating GSDMB pore formation: to ignite or inhibit?
In the recent Nature, Wang et al. and Zhong et al. present the cryo-EM structures of Gasdermin B (GSDMB) pore and strucures of GSDMB in complex with a Shigella effector, IpaH7.8. The structures shed light on the ...
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Article
Open AccessStructural basis for GSDMB pore formation and its targeting by IpaH7.8
Gasdermins (GSDMs) are pore-forming proteins that play critical roles in host defence through pyroptosis1,2. Among GSDMs, GSDMB is unique owing to its distinct lipid-binding profile and a lack of consensus on its...
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Article
Open Access3D Artificial Array Interface Engineering Enabling Dendrite-Free Stable Zn Metal Anode
The design concept of 3D artificial array interface engineering was proposed to achieve eliminated volume stress, preferred orientation growth and dendrite-free Zn metal anode.
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Article
Open AccessMechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes
NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular signalling complexes known as canonical inflammasomes, resulting in caspase−1 activation, cytokine maturation and/or pyrop...
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Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation
In the version of this article initially published, the label (CASP4-C285A-HA) above the second and fifth lanes in the right blot in Fig. 1e is incorrect; the correct label is CASP4-C258A-HA. Also, the two labels...
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Article
Open AccessPlasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2
Absent in melanoma 2 (AIM2) is an essential cytosolic double-stranded DNA receptor that assembles with the adaptor, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspa...