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Gasdermin D pore structure reveals preferential release of mature interleukin-1

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  1. Article

    Open Access

    Structural basis for GSDMB pore formation and its targeting by IpaH7.8

    Gasdermins (GSDMs) are pore-forming proteins that play critical roles in host defence through pyroptosis1,2. Among GSDMs, GSDMB is unique owing to its distinct lipid-binding profile and a lack of consensus on its...

    Chengliang Wang, Sonia Shivcharan, Tian Tian, Skylar Wright, Danyang Ma… in Nature (2023)

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  2. Article

    Open Access

    Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes

    NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular signalling complexes known as canonical inflammasomes, resulting in caspase−1 activation, cytokine maturation and/or pyrop...

    L. Robert Hollingsworth, Liron David, Yang Li, Andrew R. Griswold… in Nature Communications (2021)

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