180 Result(s)

Article

Clinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma

Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data sh...

Yanni Wang, Chang Liu, Huan Chen, ** Jiao… in Signal Transduction and Targeted Therapy (2024)

Article

DUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma

Lung adenocarcinoma (LUAD) patients have a dismal survival rate because of cancer metastasis and drug resistance. The study aims to identify the genes that concurrently modulate EMT, metastasis and EGFR-TKI re...

Weina Fan, Ying **ng, Shi Yan, Wei Liu, **feng Ning… in Cancer Cell International (2024)

Article

Tunlametinib (HL-085) plus vemurafenib in patients with advanced BRAF V600-mutant solid tumors: an open-label, single-arm, multicenter, phase I study

Tunlametinib (HL-085) is a novel, highly selective MEK inhibitor with substantial clinical activities in patients with NRAS-mutant melanoma. This phase I study evaluated the safety and preliminary efficacy of tun...

Yuankai Shi, **aohong Han, Qian Zhao, YuLong Zheng… in Experimental Hematology & Oncology (2024)

Article

Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection

The immunoprotective components control COVID-19 disease severity, as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity, remain uncl...

Gang Yang, **peng Cao, Jian Qin, **nyue Mei… in Signal Transduction and Targeted Therapy (2024)

Article

The efficacy and safety of adding PD-1 blockade to induction chemotherapy and concurrent chemoradiotherapy (IC-CCRT) for locoregionally advanced nasopharyngeal carcinoma: an observational, propensity score-matched analysis

Despite the success of PD-1 blockade in recurrent/metastatic nasopharyngeal carcinoma (NPC), its effect for locoregionally advanced NPC (LANPC) remains unclear. This study aimed to evaluate the benefit of addi...

Ya-Nan **, Meng-Yun Qiang, Ying Wang, Yu-**g Lin… in Cancer Immunology, Immunotherapy (2024)

Article

Polymorphism rs2327430 in TCF21 predicts the risk and prognosis of gastric cancer by affecting the binding between TFAP2A and TCF21

Single nuclear polymorphisms (SNPs) have been published to be correlated with multiple diseases. Transcription Factor 21 (TCF21) is a critical transcription factor involved in various types of cancers. However...

**nyi Zhou, Kuan Shen, Shuqing Cao, Pengyu Li, Jian **ao… in Cancer Cell International (2024)

Article

Prognostic value of baseline neutrophil/lymphocyte ratio in HER2-positive metastatic breast cancer: exploratory analysis of data from the CLEOPATRA trial

This study aimed to evaluate the prognostic role of the baseline neutrophil/lymphocyte ratio (NLR) in HER2-positive metastatic breast cancer (MBC) patients treated with trastuzumab/pertuzumab.

Nianhua Ding, Jian Pang, Xuan Liu, **ongbin He, Wei Zhou… in Breast Cancer Research (2024)

Article

Retraction Note to: Mesothelial cells differentiate into fibroblast-like cells under the scirrhous gastric cancer microenvironment and promote peritoneal carcinomatosis in vitro and in vivo

Zhi-Dong Lv, Hai-Bo Wang, Qian Dong, Bin Kong… in Molecular and Cellular Biochemistry (2024)

Article

Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2

The aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells both in vitro and in vivo, of...

Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu… in BMC Cancer (2023)

Article

Retraction Note: 8-bromo-7-methoxychrysin suppress stemness of SMMC-7721 cells induced by co-culture of liver cancer stem-like cells with hepatic stellate cells

Qi Wen, Chang Xu, Jie Zhou, Nuo-Min Liu, Ying-Hong Cui, Mei-Fang Quan… in BMC Cancer (2023)

Article

Correction: UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expression of PDK1 through PI3K/AKT signaling

Jian-**an Lin, **n-Sheng **e… in Journal of Experimental & Clinical Cancer … (2023)

Article

CDK5 promotes apoptosis and attenuates chemoresistance in gastric cancer via E2F1 signaling

Chemoresistance is a major clinical challenge that leads to tumor metastasis and poor clinical outcome. The mechanisms underlying gastric cancer resistance to chemotherapy are still unclear.

Long-Long Cao, Yu-Kai Wu, Tong-**n Lin, Mi Lin, Yu-**g Chen… in Cancer Cell International (2023)

Article

Evaluation of dynamic recurrence risk for locally advanced gastric cancer in the clinical setting of adjuvant chemotherapy: a real-world study with IPTW-based conditional recurrence analysis

The long-term dynamic recurrence hazard of locally advanced gastric cancer (LAGC) in the clinical setting of adjuvant chemotherapy (ACT) remains unclear.

Dong Wu, Jun Lu, Zhen Xue, Qing Zhong, Bin-bin Xu, Hua-Long Zheng… in BMC Cancer (2023)

Article

Necroptosis-related LncRNAs in skin cutaneous melanoma: evaluating prognosis, predicting immunity, and guiding therapy

An increasing amount of research has speculated that necroptosis could be a therapeutic strategy for treating cancer. However, understanding the prognostic value of the necroptosis-related long non-coding RNAs...

Jianlan Liu, Binlin Luo, Pengpeng Zhang, Keyu Jiang, Zuoqiong Hou… in BMC Cancer (2023)

Article

Envonalkib versus crizotinib for treatment-naive ALK-positive non-small cell lung cancer: a randomized, multicenter, open-label, phase III trial

Anaplastic lymphoma kinase (ALK) rearrangements are present in about 5–6% of non-small cell lung cancer (NSCLC) cases and associated with increased risks of central nervous system (CNS) involvement. Envonalkib...

Yunpeng Yang, Jie Min, Nong Yang, Qitao Yu… in Signal Transduction and Targeted Therapy (2023)

Article

High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

Normal high-density lipoprotein (nHDL) can induce angiogenesis in healthy individuals. However, HDL from patients with coronary artery disease undergoes various modifications, becomes dysfunctional (dHDL), and...

Zhi-Wei Mo, Yue-Ming Peng, Yi-**n Zhang, Yan Li… in Signal Transduction and Targeted Therapy (2023)